幽门螺杆菌感染对十二指肠球部溃疡患者血清il6、il8及no的影响

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1、幽门螺杆菌感染对十二指肠球部溃疡患者血清IL6、IL8及NO的影响作者：王光余，黄晓辉，吴国平【摘要】目的：探讨幽门螺杆菌(Hp)感染对十二指肠球部溃疡患者血清白细胞介素6、8(IL6、IL8)及一氧化氮(NO)的影响。方法：分别采用双抗体夹心ELISA法和硝酸还原酶法检测40例Hp感染的十二指肠球部溃疡患者(根除Hp组和未根除Hp组)治疗前、后和10例正常对照组血清中IL6、IL8及NO水平的变化，并进行比较。结果：治疗2周后根除Hp组血清IL6、IL8及NO水平高于正常对照组，但差异无统计学意义(P>0.05)，未根除Hp组血清IL6、IL8及NO水平

2、明显高于正常对照组，差异有统计学意义(P<0.01);根除Hp组治疗后IL6、IL8及NO水平较治疗前均有显著下降(P<0.01),而未根除Hp组治疗后IL6、IL8及NO水平较治疗前也均有下降，但差异无统计学意义(P>0.05);与未根除Hp组比较，根除Hp组治疗后IL6、IL8及NO均有显著下降(P<0.01)。结论：Hp感染的十二指肠球部溃疡存在不同程度炎症，而且Hp对炎症起促进作用，根除Hp对其炎症反应起到明显抑制作用。【关键词】幽门螺杆菌;十二指肠球部溃疡;白细胞介素6;白细胞介素8;一氧化氮9[ABSTRACT]Objective:T

3、oinvestigatetheinfluenceofHelicobacterpylori(HP)infectiononserumIL6,IL8andNOinduodenalulcerpatients.Methods:FortypatientswithduodenalulcerwithHPinfectionweredividedrandomlyintotwogroups(groupAandB),HPinpatientsofgroupAandBwaseradicatedandwasnoteradicatedaftertreatmentrespectively,10healthsub

4、jectswithoutHPinfectionandDUwereenrolledasgroupC(controlgroup);doubleantibodysandwichELISAandnitratereductaseassaywereemployedtodeterminelevelsofserumIL6,IL8andNOinpatientsofgroupAandBbeforeandaftertreatment,andthoseinpatientsofgroupC,andcomparisonwasdoneamongthem.Results:Aftertreatmentof2w

5、eeks,levelsofIL6,IL8andNOingroupAwerehigherthanthoseingroupC,butthedifferencewasnotsignificant(P>0.05);levelsofIL6,IL8andNOingroupBweremarkedlyhigherthanthoseingroupC,andthedifferencewassignificant(P<0.01);levelsofIL6,IL8andNOingroupAdecreasedcomparedthosewithbeforetreatment,andthe

6、differencewassignificant(P<0.01);levelsofIL6,IL8andNOingroupBdecreasedcomparedthosewithbeforetreatment,andthedifferencewasnotsignificant(P>0.05);comparedlevelsofIL6,IL8andNOaftertreatmentbetween9groupAandB,whichdecreasedsignificantlyingroupA(P<0.01).Conclusion:PatientswithDUandHPh

7、aveinflammationbyvarioudegrees,andHPmaydeteriorateinflammation,anderadicationofHPcaninhibittheinflammatoryreactionsapparently.　　[KEYWORDS]Helicobacterpylori(HP);Duodenalulcer(DU);Interleukin6(IL6);Interleukin8(IL8);Nitricoxide(NO)