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1、川芎嗪治疗新生儿缺氧缺血性脑病临床研究【关键词】川芎嗪；新生儿；缺氧缺血性脑病；血钙；自由基 【摘要】目的探讨川芎嗪治疗新生儿缺氧缺血性脑病的疗效和安全性。方法将42例缺氧缺血性脑病新生儿随机分为研究组（基本治疗+川芎嗪治疗）23例，对照组（基本治疗）19例，同时选取10例健康儿为健康组。对三组患儿治疗前后一氧化氮、丙二醛、神经元特异性烯醇化酶、血钙、新生儿神经行为量表评分变化进行比较分析。结果入院1～2d研究组与对照组血钙无明显差异(t=0.893,P＞0.05),且均低于健康组(t=4.866,4.803,P＜0.05);10～11d后
2、,治疗组上升明显高于对照组(t=2.341,P＜0.05);血浆一氧化氮、丙二醛治疗前研究组与对照组无明显差异,研究组治疗后较治疗前明显下降,与对照组比较差异显著(t=3.76,2.13,P＜0.05);研究组与对照组治疗前神经元特异性烯醇化酶无显著差异(t=0.243,P＞0.05),两组较健康组高(t=6.09,5077,P＜0.01)，研究组治疗后较治疗前显著降低(t=9.15,P＜0.01),对照组治疗前与治疗后无显著差异(t=1.839,P＞0.05);研究组与对照组治疗前新生儿神经行为量表评分无显著差异,治疗后研究组较对照组评分差
3、异明显(P＜0.05)。结论 川芎嗪可通过阻止钙内流,减少自由基，对缺氧缺血性脑病新生儿脑组织具有保护作用。 【关键词】川芎嗪；新生儿；缺氧缺血性脑病；血钙；自由基10 Clinicalstudyonthetetramethylphylpyrazineinthetreatmentofneonatalhypoxicischemicencephalopathy 【Abstract】ObjectiveToexplorethecurativeeffectsandsafetyofthetetramethylphylpyrazine(TMPZ)in
4、thetreatmentofneonateswithhypoxicischemicencephalopathy(HIE).Methods42neonateswithHIEwererandomlydividedintoresearchgroup(n=23,basicctreatmentcombinedwithTMPZ)andcontrolgroup(n=19,singlebasictreatment),and10healthyneonatesselectedashealthygroup.Beforeandaftertreatment,compa
5、rativeanalysesofnitricoxide(NO),malondialdehyde(MDA),Neuronspecificenolase(NSE),serumcalciumandthescoresofNeonatalNeuroBehaviorAssessmentScale(NNBAS)wereconductedamongthe3groups.ResultsInthe1stand2nddaysofadmission,serumcalciumoftheresearchandcontrolgroupshadnodifference(P&
6、gt;0.05)andbothwerelowerthanthehealthygroup(P<0.05);after10~11days,serumcalciumwassignificantlyhigherintheresearchthanthatinthecontrolgroup(P<0.05);beforetreatmenttherewerenoobviousdifferencesinplasmaNOandMDAbetweentheresearchgroupandcontrolgroup,theNOandMDAofposttrea
7、tmentwere10significantlylowerthanthoseofpretreatmentandhadsignificantdifferencefromthecontrolgroup(P<0.05);beforetreatment,theNSEoftheresearchandcontrolgroupshadnosignificantdifference(P>0.05)andbothwerehigherthanthehealthygroup(P<0.01),thatoftheresearchwassignific
8、antlyloweraftertreatmentthanbeforetreatment(P<0.01)andthatofthecontrolhadnoobvi
