左氧氟沙星序贯疗法治疗老年人下呼吸道细菌感染的效果分析

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1、左氧氟沙星序贯疗法治疗老年人下呼吸道细菌感染的效果分析【摘要】目的:评价盐酸左氧氟沙星序贯疗法治疗老年人下呼吸道细菌感染的临床疗效和经济效果。方法:78例下呼吸道细菌性感染老年患者随机分为两组,序贯组(Ａ组)42例,采用盐酸左氧氟沙星500ｍｇ/ｄ,静脉滴注2ｄ～4ｄ,继之以盐酸左氧氟沙星胶囊500ｍｇ/ｄ,口服5ｄ～10ｄ;对照组(Ｂ组)36例,采用盐酸左氧氟沙星500ｍｇ/ｄ,静脉滴注,疗程7ｄ～14ｄ。治疗结束后进行成本效果分析。结果:Ａ、Ｂ两组痊愈率分别为50.0%和52.8%,有效率分别为85.7%和83.3%,细菌清除率分别为84.8%和83.9%,不良反应发生

2、率分别为4.8%和2.8%;经统计学比较,两组疗效相似(Ｐ>005),但Ａ组的成本效果比低于Ｂ组。结论:盐酸左氧氟沙星序贯疗法与单纯静脉滴注治疗相比,两者临床疗效相似,但前者显著降低了总医疗费用,值得临床应用推广。【关键词】下呼吸道细菌感染；盐酸左氧氟沙星；序贯疗法；效果分析　　CosteffectivenessAnalysisofSequentialTherapyofLevofloxacinHydrochlorideforBacterialinfectionofLowerRespitatoryTract10　　Abstract:ObjectiveToevaluat

3、eclinicaltherapeuticeffectandeconomiceffectsofsequentialtherapyoflevofloxacinhydrochlorideforbacterialinfectionofLowerrespitatorytract(LRT).Methods78caseswithbacterialinfectionofLRTwererandomlydividedintotwogroups.43casesinsequentialgroup(groupA)weretreatedwithIVinjectionoflevofloxacinhydro

4、chloride500mg/dfor2days～4days,thentooklevofloxacinhydrochloridecapsules500mg/dfor5days～10days;36casesincontrolgroup(groupB)weretreatedwithIVinjectionoflevofloxacinhydrochloride500mg/dfor7days～14days.Costeffectivenessanalysisweremadeafterendingthetreatment.ResultsThehealingrateofgroupAandgr

5、oupBwasrespectively50.0%and52.8%;theeffectiveratewasrespectively85.7%and83.3%;bacteriaclearanceratewasrespectively84.8%and83.9%;theincidencerateofadversereactionswasrespectively4.8%and2.8%.Bystatisticalcomparison,therapeuticeffectbetweenthetwogroupwassimila(P>0.05),butcosteffectivenessr

6、atioingroupAwaslowerthanthatingroupB.ConclusionComparisonbetweensequentialtherapyoflevofloxacinhydrochlorideandsimpleIVinjectionisfoundtobesimilarinclinicaltheraputiceffect,buttheformer10obviouslydecreasestotalmedicalcost,soitisworthytobespreadintheclinic.　　Keywords:Lowerrespitatorytractbac

7、terialinfection;Levofloxacinhydrochloride;Sequentialtherapy;Costeffectivenessanalysis　　在我国,目前临床使用的抗生素品种繁多,抗生素的用药金额已占到药品总金额的40%左右,而用药费用已占到医疗总费用的50%左右［1］。左氧氟沙星是氟喹诺酮类抗菌新药,与沿用氟喹诺酮类抗生素相比,增强了对革兰阳性球菌的抗菌活性,但仍保持了对需氧革兰阴性杆菌的良好抗菌作用［2，3］，其口服制剂吸收完全,生物利用度近100%,此药代动力学特