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1、冠心病患者血清MMP-9水平测定及临床意义【摘要】目的观察不同类型冠心病患者血清基质金属蛋白酶-9的水平变化，探讨MMP-9与冠心病的关系。方法选取我院心内科及湘雅二医院2006年9月～2007年4月入院诊断为冠心病的患者101例，其中最后诊断为急性心肌梗死（AMI）33例，不稳定型心绞痛（UAP）37例，稳定型心绞痛（SAP）31例。健康对照组（C）20例。采用双抗体夹心酶联免疫吸附试验（ELISA）测定血清MMP-9的水平。结果（1）AMI组、UAP组与SAP组患者血清基质金属蛋白酶-9（MM
2、P-9）水平均显著高于对照组（P＜0.01，P＜0.01,P＜0.05）。（2）AMI组与UAP组患者血清MMP-9水平均显著高于SAP组（P均＜0.01）。（3）AMI组患者MMP-9水平与UAP组比较差异有显著统计学意义（P＜0.01）。（4）按SAP、UAP到AMI由轻到重的等级排列，MMP-9的水平由低到高依序增高。结论冠心病患者血清MMP-9水平升高。血清MMP-9水平增高提示斑块的不稳定性，同时也可以作为冠心病患者危险分层的一个重要生化监测指标，预测急性冠脉事件的发生。【关键词】冠心病
3、急性心肌梗死不稳定型心绞痛稳定型心绞痛基质金属蛋白酶-9MeasurementandclinicalsignificanceonserumMMP-9inpatientswithcoronaryheartdisease10［Abstract］ObjectiveToobservethefluctuationofserummatrixmetalloproteinases-9（MMP-9）indifferenttypesofcoronaryheartdiseasepatients,anddiscussth
4、erelationbetweenMMP-9andcoronaryheartdisease.Methods101patientswerechosenwithfirstimpressionofcoronaryheartdiseasefromSeptember2006toApril2007intwohospitals,themedicalheartwardoftheeighthhospitalinChangshaandsecondaffiliatedhospitalofXiangyaUniversity
5、,atlast,inwhich33patientswerediagnosedwithAcuteMyocardialInfarction（AMI）,37patientswithUnstableAnginaPectoris（UAP）,31patientswithStableAnginaPectoris（SAP）.20healthypeoplewerechosenascomparisonteam（C）.ThemethodofTwoAntibody“Sandwich”Enzyme-LinkedImmuno
6、sorbentAssay（ELISA）wasusedtodeterminetheconcentrationofserumMMP-9.Results（1）Theconcentrationsofserummatrixmetalloproteinases-9（MMP-9）inAMIpatients,UAPpatients,SAPpatientswereallsignificantlyhigherthaninthehealthypeopleofcomparisonteam（P<0.01,P<0
7、.01,P<0.05）.（2）Theconcentrationsofmatrixmetalloproteinases-9（MMP-9）inAMIpatients,UAPpatientsweresignificantlyhigherthaninpatientswithSAP（Pall<0.01）.（3）ComparedthedifferentconcentrationsofserumMMP-9betweenthepatientswithAMIandthepatientswith10UAP
8、,thereweresignificantmeanings（P<0.01）.（4）FromlesssevereSAP,UAPtomoresevereAMI,themoresevereofthediseasewas,thehigherconcentrationsoftheserumMMP-9were.ConclusionTheconcentrationofserumMMP-9willincreaseinpatientswithcoronaryheartdisease.Thein
