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1、64层螺旋CT灌注成像在食管癌放疗中的应用【摘要】目的:探讨64层螺旋CT灌注成像在食管癌放疗方面的价值。方法:38例经病理学证实的食管癌患者在放疗前后分别行64层螺旋CT灌注扫描,将放疗前、后的灌注参数进行配对设计t检验。放疗后随访12~18个月,中位时间15个月,再以是否局部复发和(或)转移为标准进行分组,并对各组病例放疗前肿瘤灌注参数进行独立样本t检验。结果:38例放疗前组织血流量、血容量、表面通透性、平均通过时间、强化峰值分别为(341.2±137.5)ml·100g-1·min-1,(10.4±6.8)ml·100g-1,(28
2、.3±17.1)ml·100g-1·min-1,(4.3±1.8)s,(55.9±14.7)Hu,放疗灌注后参数分别为(331.4±121.0)ml·100g-1·min-1,(8.8±5.1)ml·100g-1,(9.6±8.9)ml·100g-1·min-1,(3.5±2.0)s,(46.6±13.5)Hu。肿瘤表面通透性,强化峰值差异有统计学意义。其余各参数之间比较差异无统计学意义。复发/转移组与无复发/转移组灌注参数差异无统计学意义。结论:灌注参数可以定量反映食管癌的微循环特征。放疗前和放疗后肿瘤表面通透性、强化峰值表现为明显减低
3、。灌注参数难以预测肿瘤放疗后复发及转移。【关键词】螺旋CT;食管肿瘤;灌注成像;放射治疗[Abstract]Objective:Toassessthevalueof64slice9spiralCTindiagnosisofesophagealcarcinomaandprediction.Methods:thirtyeightcasesofesophagealcarcinomaprovedbynasopharyngoscopybiopsyunderwent64sliceCTperfusionimagingbeforeradiother
4、apy,pairedsamplesttestwasusedtoanalystheperfusionparametersofpreradiationandpostradiation,38caseswerefollowedupfor12~18months,withmedianof15months.Thecasesweredividedintogroupsaccordingtowhethertheyhadlocalrecurrenceor/andmetastasis.Theparametersofthosegroupsbeforeradi
5、otherapywereassessedwithindependentsamplettest.Results:Beforeradiotherapy,thetissuebloodflow(BF),bloodvolume(BV),surfacepermeability(PS),meantransittime(MTT),peakheight(PH)of38caseswere(341.2±137.5)ml·100g-1·min-1,(10.4±6.8)ml·100g-1,(28.3±17.1)ml·100g-1·min-1,(4.3±1.8)
6、s,(55.9±14.7)Hu.Afterradiationof60~64Gy,theseparameterswere(331.4±121.0)ml·100g-1·min-1,(8.8±5.1)ml·100g-1,(9.6±8.9)ml·100g-1·min-1,(3.5±2.0)s,(46.6±13.5)Hurespectivelyonpairedsamplesttest.TherewassignificantdifferenceinPH,PSbetweenperandpostradiationdata,whiletherewas
7、nostatisticsignificantdifferenceinotherparameters.Betweenthegroupwithrecurrenceor/andmetastasisandothergroups,9therewasnostatisticdifferenceinparametersofperfusionbeforeradiotherapy.Conclusion:PerfusionCTcanreflectthemicrocirculationfeaturesofesophagealcarcinomaquantitati
8、vely.Peakheightdecreasedsignificantlycomparedwiththatofperradiation.Itisdifficulttopredictrecur