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1、大黄对胃癌手术患者急性炎性反应的调理作用作者:蔡骏,宣正荣,卫勇平,杨海波,王华【关键词】胃肿瘤[摘要]目的:观察胃癌患者围手术期使用中药大黄对急性炎性反应的调理作用。方法:采用前瞻性、随机、单盲、对照研究,将31例胃癌手术患者随机分为对照组(肠内营养组)14例和研究组(大黄加肠内营养组)17例。研究组术前、术后第1、2天经鼻饲管给予中药大黄,两组患者手术后36h开始给予等热量、等氮肠内营养支持6d。术前1天,术后第1、3、7天分别检测血清C反应蛋白(Creactiveprotein,CRP)、白
2、细胞介素6(interleukin6,IL6)、肿瘤坏死因子α(tumornecrosisfactorα,TNFα)等急性炎性反应指标及血清白蛋白、前白蛋白、转铁蛋白等营养指标。结果:两组患者术后均有急性炎性反应的发生及营养指标的下降,但研究组术后第3、7天的CRP、IL6、TNFα水平较对照组有显著下降,术后排气、排便时间和肠鸣音的恢复显著提前。术后的营养指标两组患者间无明显差异。结论:胃癌患者围手术期应用大黄可以缓解急性炎性反应,促进术后胃肠道功能恢复,有利于实施术后肠内营养支持。10[关键词
3、]胃肿瘤;大黄;细胞因子;肠道营养EffectsofperioperativeadministrationofrhubarbonacuteinflammatoryresponseinpatientswithgastriccancerABSTRACTObjective:Toobservetheeffectofperioperativeadministrationofrhubarbontheacuteinflammatoryresponseinpatientswithgastriccancer.Met
4、hods:Inthisprospective,singleblinded,controlledclinicaltrial,thirtyonepatientswithgastriccanceroperativelytreatedwererandomlydividedintotwogroups,with14patientsincontrolgroupand17instudygroup.Patientsinbothgroupsweregivenanisocaloricandisonitrogenouse
5、nteraldiet.Theenteraldietwasstarted36hoursafteroperation,andcontinuedfor6days.Patientsinthestudygroupwerefedwithrhubarbbeforeoperation,andat1dayand2daysafteroperation.IndexesofacuteinflammatoryresponsesuchasserumCreactiveprotein(CRP),interleukin6(IL6)
6、andtumornecrosisfactorα(TNFα),andindexesofnutritionalstatussuchasserumalbumin(ALB),prealbumin(PA)andtransferrin(TRF)weremeasuredbeforeoperation,andat1day,3and7daysafteroperation.Results:Patientsinbothgroupshadacuteinflammatoryresponse,andtheindexesof1
7、0nutritionalstatusdecreasedafteroperation.IL6,CRPandTNFαtestedat3and7daysafteroperationwerelowerinthestudygroupascomparedwiththoseinthecontrolgroup,andtherecoverytimeofgastrointestinalmotilitysuchasborborygmus,gaseliminationanddefecationwasshorterinth
8、estudygroupascomparedwiththatinthecontrolgroup.Theindexesofnutritionalstatusshowednosignificantdifferencesbetweentwogroupsafteroperation.Conclusion:Rhubarbcanpositivelymodulatetheacuteinflammatoryresponse,promotetherecoveryofpostoperativegastr