pparγ和mmp9在妊娠期高血压疾病患者胎盘组织的表达及其临床意义

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1、PPARγ和MMP9在妊娠期高血压疾病患者胎盘组织的表达及其临床意义【摘要】目的探讨PPARγ和MMP9在妊娠期高血压疾病(HDCP)发生发展中的表达及其临床意义。方法利用免疫组化SP法检测正常妊娠者31例(对照组)和HDCP患者36例(实验组)胎盘组织中PPARγ、MMP9表达,探讨其与HDCP的关系。结果①PPARγ在实验组胎盘组织中明显高表达,与对照组比较有显著差异(P<0.05),PPARγ阳性表达率随病情加重而显著增高。②MMP9在实验组胎盘组织中呈低表达,与对照组比较有显著差异(P<0.05)，MMP9阳性表达率随病情加重而显著降低。③

2、PPARγ与MMP9的Pearman相关分析显示二者表达水平呈负相关(r=-0.529，P<0.01)。结论PPARγ在HDCP患者胎盘中呈高表达，MMP9在HDCP患者胎盘中呈低表达,提示其可能通过抑制滋养细胞的浸润能力而参与HDCP的发病。【关键词】过氧化物酶体增殖物激活受体γ;基质金属蛋白酶9;妊娠期高血压疾病;胎盘;免疫组化　　ABSTRACT:ObjectiveToinvestigatetheexpressionsandclinicalsignificanceofPPARγandMMP9inthegenesisanddevelopmentofhy

3、pertensivedisordercomplicatingpregnancy(HDCP).MethodsTheexpressionsofPPARγandMMP9inplacentaof31normalpregnantwomen(controlgroup)and36pregnantwomen11withhypertensivedisordercomplicatingpregnancy(experimentalgroup)weredetectedbyusingSPmethodofimmunohistochemistry,andtherelationshipbetwe

4、enPPARγandMMP9expressionsandhypertensivedisordercomplicatingpregnancywasexplored.Results①PPARγexpressioninplacentaltissueswassignificantlyhigherintheexperimentalgroupthaninthecontrolgroup(P<0.05);PPARγwithpositiveexpressionrateofexacerbationswassignificantlyincreased.②MMP9expressio

5、ninplacentaltissuesshowedlowexpressionintheexperimentalgroup,whichwassignificantlydifferentfromthatinthecontrolgroup(P<0.05);MMP9withpositiveexpressionrateofexacerbationswassignificantlydecreased.③ThePearmancorrelationanalysisofPPARγandMMP9showedthattheexpressionlevelofthetwohadaneg

6、ativecorrelation(r=-0.529,P<0.01).ConclusionPPARγhasahighexpressionintheplacentaofpatientswithHDCPwhileMMP9hasalowexpression,suggestingthattheymaybeinvolvedinthepathogenesisofHDCPbyinhibitingtheinfiltrationcapacityofnourishingcells.　　KEYWORDS:peroxisomeproliferationactivatedreceptor

7、γ(PPARγ);matrixmetalloproteinase9;(MMP9);11hypertensivedisordercomplicatingpregnancy(HDCP);placenta;immunohistochemistry　妊娠期高血压疾病(HDCP)是妊娠期特有的疾病,我国发病率为9.4%～10.4%,严重影响母婴健康,是孕产妇和围生儿患病率及死亡率的主要原因,发病机制不明。最近研究发现滋养细胞浸润能力下降是HDCP的主要原因之一[1]。过氧化物酶体增殖物激活受体γ(peroxisomeproliferation