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ID:15108547
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时间:2018-08-01
《folfox-6化疗方案治疗结直肠癌疗效观察》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、FolFox-6化疗方案治疗结直肠癌疗效观察作者:王智勇,陶凯雄,龙跃平,王国斌【摘要】目的探讨新辅助化疗FolFox-6方案治疗结直肠癌的疗效及其对术后并发症和预后的影响。方法筛选我院胃肠外科2005年10月~2008年10月结直肠癌合适病例60例,分为两组,治疗组(n=28)按FolFox-6方案术前化疗一次,14天后手术;术后再次按FolFox-6方案化疗,14天重复,共化疗4次。对照组(n=32)不做术前化疗,术后化疗与治疗组相同,采用WHO推荐的实体瘤近期疗效评价标准对治疗组行新辅助化疗后的疗效进行评估,采
2、用WHO抗癌药物常见不良反应分级标准评价新辅助化疗后的不良反应,统计两组患者术后并发症,患者恢复情况,并对两组患者进行术后随访,评估预后情况。结果治疗组行新辅助化疗后有效率(RR)多在60%以上;新辅助化疗的不良反应均短暂且较轻;两组患者术后并发症发生率差异无统计学意义;治疗组局部复发率(13.04%)明显低于对照组(31.03%);两组患者远期生存率分别为86.96%和82.76%,差异无统计学意义。结论新辅助化疗治疗结直肠癌可提高化疗疗效和降低局部复发率,但对远期生存获益的效果还有待进一步观察。【关键词】结直肠癌
3、;新辅助化疗;预后;术后并发症[Abstract]ObjectiveToinvestigateandevaluatethe11effectofneoadjuvantchemotherapyoncolorectalcarcinomaanditspostoperativecomplicationsandprognosis.MethodsScreened60casesofcolorectalcarcinomapatientsfromOctober,2005toOctober,2008inthedepartmentofGen
4、eralSurgery,UnionHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology.Dividedthemintotwogroups,onewastreatmentgroup(n=28),practicedtheprogramofFolFox-6preoperativechemotherapyfirstly,thenanothersurgeryafterhadfinishedchemotherapyfor14daysalrea
5、dy.ThenpracticedtheprogramofFolFox-6chemotherapyagain,after14daysrestandrepeatedthechemotherapyin3times.Theotherwasthecontrolgroup(n=32)withnopreoperativechemotherapybeforethesurgeryandsamepostoperativechemotherapyaftersurgerywiththetreatmentgroup.Usedthestanda
6、rdoftheefficacyofsolidtumorinnearfuturerecommendedbyWHOtoevaluatetheefficacyofpreoperativeadjuvantchemotherapyintreatmentgroup.UsedtheWHOgradingstandardofcommontoxicityofanti-cancerdrugtoevaluatethetoxicityofpreoperativeadjuvantchemotherapy.Toaddupbothgroupsofp
7、ostoperativecomplicationsandrecovery.Finally,bothgroupsofpatientswerefolloweduptoassesstheprognosisofthesituation.ResultsMostofRRsoftreatmentgroupafterpreoperativeadjuvantchemotherapywere11above60%;thetoxicitiesofpreoperativechemotherapywereshortandlight;therew
8、erenosignificantdifferencesofpostoperativecomplicationsaftersurgeryinbothgroupsofpatients;localrecurrenceinthetreatmentgroup(13.04%)wassignificantlylowerthancontrolgroup(31.
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