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1、萱草活性成分黄酮干对糖尿病大鼠抗动脉粥样硬化活性的研究黄红焰1a,李玉白1b(湖南环境生物职业技术学院1a.宣传部;1b.教务处,湖南衡阳421005)摘要:目的研究萱草活性成份黄酮干对糖尿病大鼠血糖、血脂、血浆脂蛋白脂质过氧化的影响.方法取20只雄性大鼠(Ⅱ型糖尿病模型),随机分为2组:对照组喂普通饲料,实验组喂添加10g/kg黄酮干的饲料20周,观察血液生化指标的变化.血液生化指标采用试剂盒测定,血浆脂蛋白采用序列超速离心分离法分离.结果喂饲萱草活性成份黄酮干的糖尿病大鼠血糖为(10.3±0.7)mmol/L,动脉粥样硬化指数为0.38±0.12,血浆过氧化脂质水平为(13.7±0.
2、2)mmol/L;丙二醛(MDA)水平为(7.45±1.26)(nmol/mgHb),超氧化歧化酶(SOD)活性为(153.47±37.91)(活力单位/ml);未喂饲黄酮干的对照组糖尿病大鼠上述指标分别为(13.5±1.6)mmol/L、0.54±0.24和(20.1±2.8)mmol/L,(13.01±0.74)(nmol/mgHb),和(210.98±40.11)(活力单位/ml),差异有显著性.结论萱草活性成份黄酮干具有明显的降低血糖、改善动脉粥样硬化指数、抑制脂质过氧化的作用.关键词:萱草;黄酮干;糖尿病;动脉粥样硬化Anti-atheroscleroticeffectoffl
3、avoneofHemerocallisfulvaL.ArticleingredientindiabeticratsHuangHong-yan1a,LIYu-bai1b,1a:propagandadepartment1b:Dean'sOffice.HunanEnvironmentBiologyProfessionalCollege,Hengyang421001,HunanProvince,China.【Abstract】ObjrctveTostudytheinfluenceofflavoneofHemerocallisfulvaL.extractcontainingonbloodgluco
4、se,bloodlipids,plasmalipidperoxideandplateletaggregationactivityindiabeticrats.MethodsDiabeticratswerefedwithfoddercontaining10g/kgofflavonefor20weeks.Theirindexofbiochemistrywereseparatedbysequentialultracentrifugation.RrsultsTwentyweeksafterexperiment,levelofbloodglucose,atheroscleroticindexand
5、plasmaleveloflipidperocidewere(10.3±0.7)mmol/L,0.38±0.12,(13.7±0.2)mmol/L,(7.45±1.26)(nmol/mgHb),(153.47±37.91)(activiteunit/ml),respectivelyindiabeticratsfedwithflavone,significantlylowerthanthoseincontrolratsnotfedwithit,(13.5±1.6)mmol/L、0.54±0.24和(20.1±2.8)mmol/L,(13.01±0.74)(nmol/mgHb),和(210.
6、98±40.11)(activiteunit/ml),respectively.Changesinalltheseindicesweresignificantlydifferentbetweenthetwogroups.Conclusinoflavonecouldsignificantlydecreasebloodglucose,impuoeveatheroscleroticindex,andinhibitlipidperooxidationandplateletaggregationindiabeticrats,whichmightbeusefulinpreventionandcont
7、rolofdiabetesmellitusanddiabetes-associatedatherosclerosis.【keywords】HemerocallisfulvaL.flavonediabetesatherosclerotic萱草,为百合科植物.《本草纲目》云:烹食可以适口,能去湿利水、除热通淋、开胸宽膈”,萱草对神经衰弱、高血压、动脉硬化、慢性肾炎、水肿患者均有治疗作用.流行病学调查结果显示,经常适量食萱草,对预防心血管