基因组甲基化研究综述

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1、目录摘要·······························································································································1Abstract·························································································································1

2、1甲基化机制··············································································································31.1动物中DNA甲基化机制··················································································31.2植物中DNA甲基化机制··································

3、················································41.3DNA甲基化与组蛋白甲基化的关系·······························································51.4甲基化DNA抑制基因转录沉默的机制·························································62甲基化研究技术············································

4、·························································72.1甲基化敏感扩增多态性·················································································82.2单分子实时测序法直接检测DNA甲基化·····················································92.3依赖于单分子纳米孔技术的测序·················

5、················································93甲基化应用···········································································································103.1DNA甲基化在植物中的应用········································································103.2DNA甲基

6、化在动物中的应用········································································104展望·······················································································································12参考文献····················································

7、·······························································13基因组DNA甲基化研究进展摘要：动植物基因组中存在广泛的DNA甲基化修饰，主要存在于CpG和CpNpG位点。作为表观遗传学最重要的现象之一，DNA甲基化在调控自身基因表达，抵御外来入侵DNA、转座子元件及转基因沉默从而维持基因组稳定等方面具有重要作用。文章主要对甲基化的发生、作用机制，甲基化研究相关技术及甲基化研究应用方面做了简要介绍。关键词：表观遗传；DNA；甲基化；甲基转移酶；组蛋白Ad

8、vancesofResearchonGenomicDNAmethylationPengfeiliu(CollegeofLifeScience，GuizhouUniversity，GuiYang550025，China)Abstract：DNAmethylationiswidelyexistinplantandanimalgenom