history and trends in bioprocessing and biotransformation - t. scheper, n. n. dutta, f. hammar

history and trends in bioprocessing and biotransformation - t. scheper, n. n. dutta, f. hammar

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时间:2018-07-27

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1、HistoryofModernGeneticsinGermanyFriederikeHammarInstituteforPhysiologicalChemistry,Johannes-Gutenberg-University,55099Mainz,Germany,e-mail:hammar@mail.uni-mainz.deThehistoryofmoderngeneticsinGermanyduringthe20thcenturyisastoryofmissedchances.IntheUSAthegeneticrevo

2、lutionopenedafascinatingnewfieldforambitiousscien-tistsandcreatedarapidlygrowingnewindustry.MeanwhileGermanystoodaside,combatingwithpoliticalandsocialrestrictions.PromisingyoungscientistswhowantedtoworkinthefieldleftGermanyfortheUS,andbigcompaniesmovedtheirfacilit

3、iesoutofthecountry.Upuntilthemiddleofthe1990smolecularbiologyinGermanyremaineda“sleepingbeauty”eventhoughmanybrilliantscientistsdidtheirjobsverywell.Thenasomewhatfunnyideachangedeverything:theGermanministerforeducationandscienceproclaimedtheBioRegiocontestinordert

4、oawardthemostpowerfulbiotechnologyregioninGermanyconcerningacademiaandespeciallyindustry.SincethenGermany’sbiotechnologyindustryhasgrownconstantlyandrapidlyduetothefoundationofanumberofsmallbiotechcompanies;bigcompanieshavere-turnedtheirinterestsandtheirinvestment

5、stoGermany,paralleledbyanimprovementinaca-demicresearchbecauseofmorefundingandbettersupportespeciallyforyoungerscientists.Inrespecttobiotechnologyandmolecularbiology,Germanyisstilladevelopingcountry,butithasstartedtomoveandtotakeitschancesinanexcitingglobalcompeti

6、tion.Keywords.History,Moleculargenetics,Biotechindustry,Genomics,Proteomics1Introduction..............................21.1TheBirthofModernGenetics.....................21.2MolecularGeneticsGrowsUp.....................41.3SequencingtheHumanGenome...................5

7、1.4TheMaxPlanckSociety........................62The1970s:The‘FirstGeneticRevolution’–andGermany?.....82.1TheMaxDelbrückCenterinBerlin-Buch..............92.2TheGermanCenterforCancerResearchinHeidelberg......102.3TheEuropeanMolecularBiologyLaboratoryinHeidelberg....

8、103The1980s:MolecularGeneticsStrugglingAgainstPoliticalForces113.1HoechstandInsulin–ANever-EndingStory............124The1990s:ANewBeginning–‘TheSecondGe

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