biochemistry 5th ed - jeremy m. berg, john l. tymoczko, lubert stryer

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1、DedicationAbouttheauthorsPrefaceToolsandTechniquesClinicalApplicationsMolecularEvolutionSupplementsSupportingBiochemistry,FifthEditionAcknowledgmentsI.TheMolecularDesignofLife1.Prelude:BiochemistryandtheGenomicRevolution1.1.DNAIllustratestheRelationbetweenFormandFunction1.2.Bioche

2、micalUnityUnderliesBiologicalDiversity1.3.ChemicalBondsinBiochemistry1.4.BiochemistryandHumanBiologyAppendix:DepictingMolecularStructures2.BiochemicalEvolution2.1.KeyOrganicMoleculesAreUsedbyLivingSystems2.2.EvolutionRequiresReproduction,Variation,andSelectivePressure2.3.EnergyTra

3、nsformationsAreNecessarytoSustainLivingSystems2.4.CellsCanRespondtoChangesinTheirEnvironmentsSummaryProblemsSelectedReadings3.ProteinStructureandFunction3.1.ProteinsAreBuiltfromaRepertoireof20AminoAcids3.2.PrimaryStructure:AminoAcidsAreLinkedbyPeptideBondstoFormPolypeptideChains3.

4、3.SecondaryStructure:PolypeptideChainsCanFoldIntoRegularStructuresSuchastheAlphaHelix,theBetaSheet,andTurnsandLoops3.4.TertiaryStructure:Water-SolubleProteinsFoldIntoCompactStructureswithNonpolarCores3.5.QuaternaryStructure:PolypeptideChainsCanAssembleIntoMultisubunitStructures3.6

5、.TheAminoAcidSequenceofaProteinDeterminesItsThree-DimensionalStructureSummaryAppendix:Acid-BaseConceptsProblemsSelectedReadings4.ExploringProteins4.1.ThePurificationofProteinsIsanEssentialFirstStepinUnderstandingTheirFunction4.2.AminoAcidSequencesCanBeDeterminedbyAutomatedEdmanDeg

6、radation4.3.ImmunologyProvidesImportantTechniqueswithWhichtoInvestigateProteins4.4.PeptidesCanBeSynthesizedbyAutomatedSolid-PhaseMethods4.5.Three-DimensionalProteinStructureCanBeDeterminedbyNMRSpectroscopyandX-RayCrystallographySummaryProblemsSelectedReadings5.DNA,RNA,andtheFlowof

7、GeneticInformation5.1.ANucleicAcidConsistsofFourKindsofBasesLinkedtoaSugar-PhosphateBackbone5.2.APairofNucleicAcidChainswithComplementarySequencesCanFormaDouble-HelicalStructure5.3.DNAIsReplicatedbyPolymerasesthatTakeInstructionsfromTemplates5.4.GeneExpressionIstheTransformationof

8、DNAInformationIntoFunctionalMolec