资源描述:
《lhrh类似物在卵巢癌治疗中的应用》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、LHRH类似物在卵巢癌治疗中的应用国外医学妇幼保健分册2003年第14卷第6期413果;④所需剂量小;③对mdrl,LRP,Topo-1I的作用有同步性.TNF在Esherichacoli中克隆成功使TNF有可能应用于临床实验和治疗癌症.但其副作用:发热寒战,乏力不适,恶心呕吐,胸痛等限制了其临床应用.目前以低剂量rHuT—NF联合化疗药是卵巢癌研究方向之一.[参考文献]11【CoukosG.RubinSC.Chemotherapyresistencelnovariancan.cer:newmolecularperspectiveslJjObstetandGynecol,1
2、998,91(5):783789[2]KigawaJ,MinagawaY,KanamoriY,etalGlutathionecon-centrationmaybeausefulpredictorofresponsetosecond—linechemotherapyinpatientswithovariancancer[J]Cancer,1998.82(4):697702[3]MaLorniW,RainaLdiG,TritareLLiE,etafTumornecrosisfacteralphaisapowerfulopoptoticinducerinlymphoidleuke
3、-miccellsexpressingtheP+17Oglycoprotein[J]IntJCancer,1996.67(2):238247.I4lKomdeurR,PlaatBEC,HoekstraHJ,etnfExpressionofp-glycoprotein,multidrugresistance—associatedprotein1andlungresistance—relatedproteininhumansofttissuesarcomasbeforeandafterhyperthermicisolatedlimbperfusionwithtu—mornecr
4、osisfacter一口andmelphalan[J]Cancer,2001,91(10):19401948[5]PrechtlS,RoellinghoffM,ScheperR,etalThemuhidrugre-sistenceprotein1:Afunctionallyimportantactivationmarkerformurineth1cellsJJJImmunol,2000,164(2):754761l6jLiburaJ,BettensF,RadkowskiA,etnf.PolymorphictumornecrosisfactermicrosatelliteTN
5、F口4isassociatedwithresis-tanceofHodgkinlymphomatochemotherapyandwithrelapsesaftertherapy[J].AnticancerRes,2002,22(2A):921—926『71GalvaniV,PremarHK,RuprehtRR,etnf.SolubletumornecrosisfactorreceptorI(sTNFRI)asaprognosticfactorinmelanomapatientsinSlovenepopulationlJjPflugersArch,2000:440(5Supp
6、1):R61—63『8lMurdochWJ.ProteolyticandcellulardeathmechanismsinovulatoryovarianrupturelJ』BiolSignalsRecept,2000,9(2):1O21149jLiJ,KelseySM,GrahnMF,etnfIncreasedactivityandsensitivityofmitOchOndrialrespiratoryenzymestotumornecro.sisfacter0一mediatedinhibitionisassociatedwithincreasedcy.totoxici
7、tyindrug—resistantleukemiccelllines[J]Blood,1996,87(6):2401241OI1OJSteinU,WaltherW,LaurencotCM,etnf.Tumornecrosisfacter—alphaandexpressionofthemuLtidrugresistance—associat.edgenesLRPandMRP[J].JNatlCancerInst,1997,89(11):807813.[11]SeongJ,MilrossCG,HunterNR,etn