Preliminary study of diffusion kurtosis imaging in thyroid nodules and its histopathologic correlation.[2017][Eur Radiol][10.1007s00330-017-4874-0]

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1、EurRadiolDOI10.1007/s00330-017-4874-0HEADANDNECKPreliminarystudyofdiffusionkurtosisimaginginthyroidnodulesanditshistopathologiccorrelation112112Ruo-yangShi&Qiu-yingYao&Qin-yiZhou&QingLu&Shi-tengSuo&JunChen&2311Wen-jieZheng&Yong-mingDai&Lian-mingWu&Jian-rongXuReceived:28November2016/Revised

2、:9March2017/Accepted:2May2017#EuropeanSocietyofRadiology2017AbstractADC,Dandcelldensity(r=−0.536,P=0.000;r=−0.570,ObjectivesToevaluatetheutilityofdiffusionkurtosisimag-P=0.000)andADC,DandVEGFexpression(r=−0.451,ing(DKI)ofpatientswiththyroidnodulesandtoassesstheP=0.000;r=−0.522,P=0.000).pro

3、bablecorrelationwithhistopathologicalfactors.ConclusionTheDKI-derivedparametersDandKdemon-MethodsThestudyincluded58consecutivepatientswiththy-stratedanadvantagecomparedtoconventionalDWIforthy-roidnoduleswhounderwentmagneticresonanceimagingroidlesiondiagnosis.Whilethehistopathologicalstudyi

4、ndi-(MRI)examination,includingDKIanddiffusion-weightedcatedthattheDvaluecorrelatedbetterwithextracellularimaging(DWI).Histopathologicalanalysisofparaffinsec-changethantheADCvalue,theKvalueprobablychangedtionsincludedcelldensityandimmunohistochemicalanalysisrelativetotheintracellularstructu

5、re.ofKi-67andvascularendothelialgrowthfactor(VEGF).KeyPointsStatisticalanalyseswereperformedusingStudent’st-test,re-•DWIandDKIparameterscanidentifyPTCfrombenignceiveroperatingcharacteristic(ROC)curvesandSpearman’sthyroidnodules.correlation.•Correlationswerefoundbetweendiffusionparametersan

6、dResultsThediffusionparameters,celldensityandimmuno-histopathologicalanalysis.histochemistryanalysisbetweenmalignantandbenignlesions•DKIobtainsbetterdiagnosticaccuracythanconventionalshowedsignificantdifferences.ThelargestareaundertheDWI.ROCcurvewasacquiredfortheDvalue(AUC=0.797).Thehighes

7、tsensitivitywasshownwiththeuseofK(thresh-KeywordsThyroidnodule.Thyroid.DWI.DKI.VEGFold=0.832,sensitivity=0.917).TheKi-67expressiongener-allystayedlow.AmoderatecorrelationwasfoundbetweenIntroductionRuo-yangShiandQiu-yingYaocontributedequallytothiswork.Reportedt