Endogenous IL-33 has no effect on the progression of fibrosis during experimental steatohepatitis.[2017][Oncotarget][10.18632_oncotarget.18335]

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1、www.impactjournals.com/oncotarget/Oncotarget,AdvancePublications2017EndogenousIL-33hasnoeffectontheprogressionoffibrosisduringexperimentalsteatohepatitisPhilippeVasseur1,2,*,SarahDion3,*,AvelineFilliol3,ValentineGenet3,CatherineLucas-Clerc4,GirardJean-Philippe5,ChristineSilvain2,6

2、,Jean-ClaudeLecron2,7,ClairePiquet-Pellorce3andMichelSamson31Serviced’Hépato-Gastroentérologie,CentreHospitalierNordDeux-Sèvres,Thouars,France2LaboratoireInflammationTissusEpithéliauxetCytokines,UniversitédePoitiers,France3InstitutNationaldelaSantéetdelaRechercheMédicale,Institutd

3、eRechercheSantéEnvironnement&Travail,UniversitédeRennes,Rennes,France4ServicedeBiochimie,CentreHospitalierUniversitaire,Rennes,UniversitédeRennes,Rennes,France5InstitutdePharmacologieetdeBiologieStructurale,CentreNationaldelaRechercheScientifique,UniversitédeToulouse,Toulouse,Fran

4、ce6Serviced’Hépato-Gastroentérologie,CentreHospitalierUniversitairedePoitiers,Poitiers,France7Serviced’ImmunologieetInflammation,CentreHospitalierUniversitairedePoitiers,Poitiers,France*TheseauthorshavecontributedequallytothisworkCorrespondenceto:MichelSamson,email:michel.samson@u

5、niv-rennes1.frKeywords:nonalcoholicsteatohepatitis,NASH,nonalcoholicfattyliverdisease,NAFLD,immunecellsReceived:December20,2016Accepted:May15,2017Published:june01,2017Copyright:Vasseuretal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense(CC-

6、BY),whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.ABSTRACTInterleukin(IL)-33hasbeenrecentlyreportedtobestronglypro-fibrogenicinvariousmodelsofliverdisease.OuraimwastostudytheroleofendogenousIL-33inadiet-inducedmod

7、elofsteatohepatitis.IL-33deficientmiceandwildtype(WT)littermatesreceivedahigh-fatdiet(HFD),orastandarddietfor12weeks.TheHFD-inducedsteatohepatitiswasassociatedwithanupregulationofIL-33transcriptsandprotein.AninsulintolerancetestrevealedlowersystemicinsulinsensitivityinIL-33-/—HFDm

8、icethaninWT-HFDmice.Nevertheless,