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1、无抽搐电休克治疗对精神障碍者脑电活动的影响及其相关因素分析第23卷第3期2010汕头大学医学院JournalofShantouUnivers/tyMedicalCollegeV0I.23No.32010无抽搐电休克治疗对精神障碍者脑电活动的影响及其相关因素分析李墨花,(汕头大学精神卫生中心,张强广东汕头515063)[摘要]目的:探讨无抽搐电休克治疗(MEET)对精神障碍者脑电活动的影响及其相关因素.方法:抽取经艇cT(治疗次数t>6次)的住院精神障碍者(46'例)的病案资料,分析抽搐发作
2、时脑电图(EEG)各个成分波(8,0,a,B波)的幅度值和治疗后I周内的EEG,以及治疗前脑电活动,刺激电量,发作后抑制指数等相关因素.结果:MELT后的EEG异常发生率比治疗前高(P<0.01);Spearman相关分析显示MECr时8,0,d和p波的幅度值与抑制指数呈显着正相关(占:P<O.05,0,a,p:P<0.01),除p波外均与刺激电量呈显着负相关(艿:P<0.05,0,a:P<0.01,盆:P>0.05),而各个波的幅度值与年龄及治疗前,后脑电活
3、动等因素的相关性分析元统计学意义.结论:MEcr对精神障碍者脑电活动有一定的影响;治疗发作时8,0,a和B波的幅度值与发作后抑制指数及刺激电量关系密切.[关键词]元抽搐电休克治疗;脑电活动;脑电图[中图分类号]R749.054;R454.1[文献标识码]A[文章编号]1007.4716(2010)03.0158.04EffectsofModifiedElectricConvulsiveTherapyonBrainElectricalActivityinthePatientswithMentalD
4、isorderandItsAJrIalysisofRelatedFactorsuMo—hua.ZHANGQiang(MentalHealthCettter,ShantouUnisersityMedicalCollege,Shantou515063,China)[Abstract]Objective:Toinvestigatetl1eeffectsofmodifiedelectricconvulsivetherapy(MECT)Onbrainelectricalac—tivityanditsrel
5、atedfactorsinthepatientswithmentaldisorder.Methods:Theclinicaldataof46inpatients(morethan6timesbyMECT)withmentaldisorderwereselected.Theamplitudevaluesofeachwaves(~,0,a,B)forEEGduringtheinducedseizureandEEGwithinaweekafterMECTandthefactorsinbrainelec
6、tricalactivitybeforetreatment,stim—ulatingelectricquantity,posfictalsuppressionindexeswereanalyzed.Results:TheabnormalincidenceforEEGafterMECTwashigherthanthatbefore(P<0.01).Spearmancorrelationanalysisimpliedthattherewasapositivecorrelationbetween
7、theamplitudevalues(~,0,a,)andpostictalsuppressionindexesduringMECF(~P<O.05,0,a,pP<0.01),therewasanegativecorrelationbetweentheamplitudevalues(~,0,a)aj1dstimulatingelectricquantity(P<0.05,0,aP<0.01).TherewasnOstatisticalsignificancebetween
8、山eamplitudevaluesofeachwavesandotherfac-totsinage.electricalactivityofbrainbefoleandafterMECT.Conclusion:Theremustbesomeinfluencestothebnelectricalactivityinthepatientswithmentaldisorder.Theamplitudevalues(8,0,a,p)duringseizurehaveintimatecorrelation