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1、1、TIMP-2在SD大鼠眼前段组织的表达眼科新进展2006年4月第26卷第4期RecAdOphthalmolVo1.26No.4April2006?257?作者简介:潘佳鸿,女.1977年6月出生,江苏吴江人,硕士.师从上海复旦大学附属华山医院眼科主任叶纹教授.联系电话:021—50250548(H);E—mail:pjh一7706@126.tomAboutPANJia.Hong:Female.borninJune.1977.Masterdegree.Tel:+86.21.50250548(H):E-mail:pjh一7706@126.tom收稿日期:2005—1l-22修回日期:2006
2、.O1.O2本文编辑:董建军基金项目:上海市科委资助课题(编号:004119018)作者单位:加0135上海市,上海浦东新区公利医院眼科(潘佳鸿);200040上海市,复旦大学附属华山医院眼科(叶纹);200o25上海市.上海交通大学医学院附属瑞金医院眼科(钟一声)Receiveddate:Nov22.2005Accepteddate:Jan2,2006岫蛐item:Sl_Ⅲ出iSdenceandTechnical~lst0eProvideFi—naneialAssistan~Prdect(No:01M119018)FromtheDepartmentofOphthal—molo~,Gongt
3、iH0s两inShanghaiPudongArea(PANJ~Hong),Shanthm"200135.China:De~rt一ofOphthalmology.HuashanHospitalAffiliatedFudanUniverd一(YEWen),Shanghai200040,China;DepartmentofOphthoi—molo~.RuifinH0s砸AffiliatednJio~tongUniversityMedi—ca/CoUeg~(ZHONGYi~ng),Shan~i200025,ChinaMMP.2,TIMP.1,TIMP.2在SD大鼠眼前段组织的表达△潘佳鸿叶纹钟一声E
4、xpressionsofmatrixmetalloproteinase-2andtissueinhibitorofmetalIoproteinase-1,2intheanteriorsegmenttissuesofnormalrateyesPANJia-Hong.YEWen,ZHONGYi—Sheng【Keywords】metrixmetalloprotelnase;tissuelnhlbltorsofmetallopro-telnase;rat;trabecularmeshwork;ciliarybody;age-relatedchanges【Abstract】ObjectiveToinv
5、estigatetheexpressionofmetrlxmetallopro-teinase-2(MMP-2)andtissueinhibitorofmetalloproteinase-1,2(TIMP-1,2)inanterlorsegmenttissuesofnormalrateyesindifferentagesandtodeterminetherolesofMMPandTIMPintrabecularoutflowanduveoscleraloutflowinnormaleyes.MethodsImmunohlstochemistrywasus~_dtodetectthePres-
6、enceofMMP-2andTIMPl.2inanteriorsegmenttissuesofnormalrateyesindifferentages.Theimmunohistochemlcalstainingwasfurtheranalyzedandtheintensityofreactionproductsweredetectedwithanimage-processingsys-tem.ResultsMMP_2andTIMP_1,2wereexpressedintheiris,ciliarybody,trabecularmeshwork.ThestainingofMMP_2wasst
7、rongerthanTIMP_1.2.TheexpresslonofMMP-2andTI1,2increasedfrominfanttoadult(2～3months),thendecreased.ConclusionMMP_2andTIMP_l,2wereprominentlyldentlfiedinregionsoftheanteriorsegmentofnormalrateYesassociatedwi
