原发性高血压患者血压变化规律及自主神经功能关系探析

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1、原发性高血压患者血压变化规律及自主神经功能关系探析【摘要】目的了解高血压病患者血压变化规律与植物神经功能的关系。方法选择高血压病患者（观察组）及血压正常者（对照组）各110例，同步进行24h动态血压和动态心电图检查，对两组患者各参数进行对照分析。结果①观察组动态血压各参数均明显高于对照组（P＜0．05～0．001），SDNN、HF低于或显著低于对照组（P＜0．05～0．01），LF、LF/HF均高于对照组（P＜0．05）。②观察组夜间血压下降率减低（P＜0．05），其心率变异性指标中，除SDNN白昼较夜间增高外（P＜0．05），其他指标无明

2、显差异。而对照组HRV各指标则与动态血压昼夜节律呈现出良好的相关性变化。结论高血压病患者交感、迷走神经功能双重受损，表现为HRV减低和昼夜节律消失。提示临床在治疗上除积极降压外，还应考虑自主神经功能的受损情况，给予相应的处理。【关键词】高血压；植物神经功能；动态血压；心率变异性RelationshipofbloodpressurevariatyregulationandplantnervefunctioninpatientswithprimuryhypertensionLIXiao-zhu,CHENEn,FENG7Pei-lan.TheCe

3、atralPeople’sHospitalofZhanjiangCity,Zhanjiang524037,China【Abstract】ObjectiveTounderstandtherelationofbloodpressurevarietyregulationandplantnervefunctioninpatientswithprimaryhypertension．MethodsChoosinghypertensionsufferers(observationset)andnormalbloodpressure(matchedcont

4、rol),110casesforeach，carryingon24hoursdynamicstatebloodpressureanddynamicstateelectrocardiogramchecksynchronously，oncheckingagainstanalysistotwosetsofeachparameterofsufferers．Results①Eachparameterofdynamilbloodpressureindservalionobviouslyhigherthaninthematchedcontrol(P＜0．

5、05～0．001)，itreflectedfor24hours，variousSDNNoffrequencycompositionwashighintheheartratevariationorobviouslyhigherinmatchedcontrol(P＜0．05～0．001)，mainlyreflectedtheLF,LF/HFwashigherthaninthematchedcontrol(P＜0．05)，mainreflectiontheHFofthepneumogastricnervestensionwaslowinthema

6、tchedcontrol(P＜0．05～0．001).②Thenighttimebloodpressuredescendaratetoturndown(P＜0．05).Intheheartratevariationindex7sign，inadditiontocomparingwithnighttime，theSDNNdaytimeincreased，otherindexsignshadnoobviousdifference.ButeachindexsignofHRVinmatchedcontrolindynamicbloodpressur

7、edayandnight,theregulationpresentedagoodrelativityvariety．ConclusionThehypertensionpatient′spneumogastricnervesfunctionisdualdamaged，expressingturndownfortheHRVwithdayandnightregulationdisappeared.Itisconsideredthatweshouldpayattentiontodecliningthebloodpressureactively，al

8、soshouldconsiderplantnervefunctiondamage.【Keywords】Hypertension；Plantnerve；Functionandgiv