卵巢癌的靶向治疗

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1、Saturday,February7,20091:00PM-2:30PMSanAntonioMarriottRiverwalkBallroomLevelSalonABCSanAntonio,TexasBeyondChemotherapy:CurrentandFutureMolecular-TargetedTherapyinOvarianCancerThisprogramissupportedbyaneducationalgrantfromMichaelV.Seiden,MD,PhDPresidentandChiefExecutiveOfficerFoxChaseCancerCen

2、terPhiladelphia,PennsylvaniaTheNeedforMolecular-TargetedTherapyGOG111:StandardofCareStudydesignCisplatin135mg2IVover24hours+Paclitaxel75mg/m2x6cycles(n=184)Cisplatin75mg/m2x6cycles+Cyclophosphamide750mg/m2IV(n=202)Patientswithsuboptimallydebulked,stageIII/IVepithelialovariancancerwithin6weekso

3、fsurgery(N=386)McGuireW,etal.NEnglJMed.1996;334:1-6.GOG111:PFSandOSMcGuireW,etal.NEnglJMed.1996;334:1-6.TreatmentNo.ProgressionFreeNo.WithTreatmentFailureTotalMedianPFS,mosCisplatin+cyclophosphamide2817420213Cisplatin+paclitaxel451391841800.10.20.30.40.50.60.70.80.91.0MonthsAfterEntryIntoSt

4、udyProportionSurvivingProgressionFree062436421218304800.10.20.30.40.50.60.70.80.91.0MonthsAfterEntryIntoStudyProportionSurviving0624364212183048TreatmentNo.AliveNo.DeadTotalMedianSurvival,mosCisplatin+cyclophosphamide6513720224Cisplatin+paclitaxel869818438PFS(P<.001)OS(P<.001)GOG218:Potential

5、NewStandardofCarePrimaryendpoint:PFSmeasuredbyRECISTSecondaryendpoints:OS,safety,QoL,translationalobjectives,response*Beginningincourse2ofchemotherapy.†Beginningincourse7ofchemotherapy.ClinicalTrials.gov.NCT00262847.PatientswithstageIII/IVovarianorprimaryperitonealcancerandGOGPS0-2entered1-12w

6、eeksafterinitialsurgery(N=2000)Paclitaxel+Carboplatin+Placebo*Paclitaxel+Carboplatin+Bevacizumab*Paclitaxel+Carboplatin+Bevacizumab*Placebo†x15monthsPlacebo†x15monthsBevacizumab†x15monthsTCGAandPredictiveMarkersTheCancerGenomeAtlasprojectCollaborationofNCIandNationalHumanGenomeResearchInstitute

7、MultidisciplinaryeffortaimedatdevelopingandevaluatingasystemforidentifyingandcharacterizinggenomicchangesassociatedwithGBM,lungcancer,andserouscanceroftheovariesOvariancancerdatanowpopulatingTheCancerGenomeAtlasdatabaseOvarianCanc