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1、JSouthMedUniv,2016,36(9):1221-1225doi10.3969/j.issn.1673-4254.2016.09.10·1221·临床研究٤บ୕ѨದಕဥбބતྟയᄣѨཌྷܱྟ周琴，李永强，祝爽爽，刘新宇，邵小飞，李宾，王晓红，张瑛，王红蕾，黎嘉敏，邓康平，刘琴，邹和群南方医科大学第三附属医院肾内科，广东广州510630摘要：目的分析非糖尿病人群中腰臀比与慢性肾脏病的相关性，比较其在男性和女性中的差异。方法选择2012年6月~10月我国南方社区居民进行横断面筛查（n=2142），排除糖尿病人群。将参与者分为男性组和女性组，并以腰臀比四分
2、位数将男女各分为4组。采用Logistic回归模型分析在非糖尿病人群中腰臀比与慢性肾脏病的相关性，并比较其在男性和女性中的差异。结果在女性非校正模型中，腰臀比与慢性肾脏病显著相关（OR7.29，95%CI3.56to16.32，P<0.001）。在校正潜在混杂因素如年龄、高血压史、冠心病史、吸烟饮酒史、收缩压、舒张压、甘油三酯、高密度脂蛋白后，二者仍相关（OR6.13，95%CI2.56to15.20，P=0.003）。在男性非校正模型中，腰臀比四分位数最高与最低组慢性肾脏病与腰臀比的OR值为2.44（95%CI，0.98to4.97，P=0.103）。结论在
3、非糖尿病人群中，女性腰臀比是慢性肾脏病独立危险因素，在男性中无相关性。关键词：腰臀比；慢性肾脏病；性别；非糖尿病人群Associationofwaist-to-hipratiowithchronickidneydiseaseinnon-diabeticsubjectsZHOUQin,LIYongqiang,ZHUShuangshuang,LIUXinyu,SHAOXiaofei,LIBin,WANGXiaohong,ZHANGYing,WANGHonglei,LIJiamin,DENGKangping,LIUQin,ZOUHequnDepartmentofNe
4、phrology,InstituteofNephrologyandUrology,ThirdAffiliatedHospitalofSouthernMedicalUniversity,Guangzhou510630,ChinaAbstract:ObjectiveToexploretherelationshipbetweenwaist-to-hipratio(WHR)andchronickidneydisease(CKD)innon-diabeticsubjectsandcomparethedifferencebetweenmaleandfemalesubjec
5、ts.MethodsWeperformedacross-sectionalsurveyamong2142community-basedsouthernChineseparticipantswithoutdiabetesfromJunetoOctober2012.Wedividedalltheparticipantsinto4groupsaccordingtothegender-specificquartilesofWHR.LogisticregressionmodelswereusedtoexploretheassociationsofWHRwithCKDin
6、thesesubjects.ResultsIntheunadjustedmodel,WHRwassignificantlyassociatedwithCKDinwomen(OR=7.29,95%CI:3.56-16.32,P<0.001),andtheassociationwasstillsignificant(OR=6.13,95%CI:2.56-15.20,P=0.003)afteradjustmentforthepotentialconfounders(includingage,historyofhypertension,coronaryheartdis
7、ease,currentsmoker,physicalinactivity,educationlevel,systolicbloodpressure,diastolicbloodpressure,serumtriglyceride,serumhighdensitylipoprotein,bloodglucose,andBMI).Theoddsratio(OR)forhavingCKDinthehighestversuslowestquartileofWHRlevelswas2.44(95%CI:0.98-4.97,P=0.103)inmenintheunadj
8、ustedmodel.Conclusi
