蚕蛹蛋白多肽保健功效的研究

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1、摘要实验研究蚕蛹蛋白多肽的保健功效，包括抗疲劳作用和免疫调节作用两个部分。抗疲劳实验将蚕蛹蛋白多肽分为高、中、低剂量组，分别为2.4、1.2、0.6g/kg·d喂饲小鼠28d，观察小鼠爬杆时间、负重游泳时间，测定血清尿素氮、肝糖原和肌糖原含量，测定游泳前、游泳后0、15、60min血清乳酸含量的变化。实验结果表明蚕蛹蛋白多肽能显著增加小鼠爬杆时间和负重游泳时间，增加小鼠运动过程中肝糖原和肌糖原含量，较少血清尿素氮的含量，并能显著降低游泳后血清乳酸的增加量；免疫调节实验也将蚕蛹蛋白多肽分为高、中、低剂量组，分别

2、为5.0、2.6、0.5g/kg·d喂饲小鼠40d，观察小鼠免疫器官指数变化、迟发型变态反应（DTH）、抗体生成细胞数和碳廓清能力等四个实验项目。实验结果表明与阴性对照组比较，蚕蛹蛋白多肽能显著增加小鼠胸腺指数，增加小鼠足跖肿胀度，增加小鼠抗体细胞生成数量，增加单核－巨噬细胞吞噬能力。实验得到如下结论：蚕蛹蛋白多肽具有明显的抗疲劳作用和免疫调节作用。关键词：蚕蛹蛋白；多肽；抗疲劳；免疫调节-IV-AbstractTheexperimentalstudyonhealthfunctionofsilkwormpup

3、aproteinpeptides,includinganti-fatigueeffectandimmuneregulationeffectsoftwoparts.Silkwormpupaproteinpolypeptideanti-fatigueisdividedintohigh,medium,andlowdosegroups,respectively,2.4,1.2,0.6g/kg·dmicefed28D,observationofclimbingtime,loadedswimmingtimeinmice,

4、determinationofureanitrogen,serumliverglycogen,andmuscleglycogencontent,determinationofswimming,swimbackbeforechangesofserumlacticacidcontentof0,15g.ExperimentalresultsindicatesthatsilkwormpupaproteinmorepeptidecansignificantlyincreasedsmallratsclimbingRodt

5、imeandloadingswimmingtime,increasedsmallratsmovementprocessintheliverglycogenoriginalandmuscleglycogencontent,lessserumureanitrogenofcontent,andcansignificantlyreduceswimmingHouserumlacticacidofincreasedvolume;immuneregulationexperimentalalsowillsilkwormpup

6、aproteinmorepeptideisdividedintohigh,andinthe,andlowdosegroup,respectivelyfor5,and2.6,and0.5G/kg·dfeedfeedingsmallrats40D,observationsmallratsimmuneorganindexchanges,andlatehairallergy(DTH),andantibodygeneratedcellnumberandcarbonclearanceability,fouraexperi

7、mentalproject.Experimentalresultsshowthat-IV-comparedwiththenegativecontrolgroup,SilkWormpupaproteinorpeptidecansignificantlyincreasethemousethymusindex,increasemousePlantarfootswelling,increasethenumberofantibodiesinmicecells,increasethephagocytosisofmonon

8、uclear-macrophage.Experimentalcometothefollowingconclusion:silkwormpupaproteinpolypeptidehasobviousanti-fatigueeffectandimmuneregulationeffects.Keywords:silkwormpupaprotein;peptide;anti-fatigue;immuner