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1、食管癌后程加速超分割放化疗及单纯超分割放疗疗效对比观察【摘要】目的比较后程加速超分割放疗加同期化疗与单纯后程加速超分割放疗治疗食管癌的近期疗效及毒副作用。方法78例中上段食管癌患者随机分为两组。1)单纯后程加速超分割放疗组36例;2)后程加速超分割放疗加同期化疗组42例。放疗采用6MVX线外照射,前2/3程常规放射治疗2Gy/次,1次/d,共40次,后1/3疗程改用加速超分割放射治疗,1.2Gy/次,2次/d,间隔6h,全疗程总剂量共65Gy;化疗采用周剂量紫杉醇全身用药方案,30mg静脉滴注,每周一放疗前给药1次,共6次,用药前给予预处理。结果同步放化疗组近期有效率
2、为83.3%,1、3、5年生存率分别为71.4%、42.8%和28.5%;单放组的近期有效率为63.8%,1、3、年生存率分别为47.2%、27.7%和13.8%。经χ�2检验,差异有显著意义,两组毒副作用均可以耐受。结论以紫杉醇化疗同步后程加速超分割放疗可以提高食管癌的近期有效率及长期生存率,毒副反应所有患者均能耐受。�【关键词】食管癌;后程加速超分割放化疗��Synchronicradiotherapy-chemotherapycomparedwithradiotherapyaloneinpatientswithupperandmiddleesophagealca
3、ncer7DINGBai-ying,XIEZhao-hui.DepartmentofRadiationoncology,ChengDeCancerHospitalchengde,067000,China�【Abstract】ObjectiveToevaluatethetoxicityandclinicalactivityoflatecourseacceleratedhyperfractionationradiotherapypluschemotherapy(LCAHR+C)andlatecourseacceleratedhyperfractionationradiot
4、herapy(LCAHR).Methods78patientswithmid-uppersegmentesophagealcarcinomawererandomlydividedintotwogroups:1)LCAFRgroup:36patients2)LCAHR+Cgroup:36patients.Weregivenwith6Mvx-ray,totaltumerclosewas40Gy/20F,withconventionalfractionationregimenduringthefirsttwo-thirdsofthecourse,andfollowedbyl
5、cahr,1.2Gyperfraction,twicedaily.Thetotalclosevariedupto65Gy.Paclitaxel30mgwasgiventhroughinstravenousdrippingforweekyadministratedonceperweekbeforeradiotherapyfor6weekswithpremedicationof1hourintravenousinfusion.ResultsTheeffectiverateofconcurrentchemotherapygroupwas783.3%,1、3、5yearsur
6、vivalrateswere71.4%、42.8%、28.5;short-termandeffectiverateoftheradiotherapywas63.8%,1、3yearsurvivalrateswere47.2%、27.7%、13.8%,bychi-squaretest,thedifferencewasstatisticallysignificant,twosideeffectsaretolerable.ConclusionIncomparisonwithHF,thecombinedtreatmenttendstopromotethesurvivalrat
7、e,yetdoesnotincreasethelateadversereactions.�【Keywords】Esophagealcancer;Synchronicradiotherapy-chemotherapy�笔者自2002年1月开始将78例中上段食管癌患者随机分为单纯后程加速超分割放疗36例,后程加速超分割放疗加同期化疗42例,进行近期疗效比较和毒副反应观察,现将结果报告如下。�1资料与方法��基金项目:承德市科研指导计划项目(项目编号:200621040)�作者单位:067000河北省承德市肿瘤医院放疗科7�1.1一般资料78例患者,男52
