资源描述：
《氯普鲁卡因与罗哌卡因用于硬膜外自控分娩镇痛的临床研究》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、氯普鲁卡因与罗哌卡因用于硬膜外自控分娩镇痛的临床研究【关键词】,氯普鲁卡因ComparisonofpatientcontrolledepiduralbolusadministrationofchloroprocaineandropivacaineforanalgesiaduringlaborGONGHui,YANJianJun,LIGongShe,ZHANGPing,ZAIMiaoQinDepartmentofAneasthesia,MaternityandChildHealthCareHospital,Xi’an710003,ShaanxiProvince,China【Abstract】AI
2、M:Tocomparetheeffectsofepidural10g/Lchloroprocaineand1.25g/Lropivacainebypatientcontrolledepiduralanalgesia(PCEA)inlabour.METHODS:FortyeightASAIorIIfirsttimelyinginwomenrequestingepiduralanalgesiainearlylaborwereallocatedtoreceiveeither10g/Lchloroprocainewith0.03g/Lfentanylor1.25g/Lropivacainewith0.
3、03g/Lfentanylviaapatientcontrolledanalgesiapump.Thepumpwasstoppedatthebeginningofthesecondstageoflabor.VisualAnalgesiaScores(VAS)andModifiedBromageScore(MBS)wereestimatedandrecordedatfourtimepoints:Beforeanalgesia,5minafterepiduralloadingdose,30minafterepiduralloadingdose,andbeginningofthesecondstag
4、eoflabor.DurationoflaborandApgarscoresat1minand5minafterparturitionwerealsocompared.RESULTS:TherewasasignificantdifferenceinVASat5minafterepiduralloadingdosebetweenthetwogroupsandnodifferencewasobservedatothertimepoints.MBS,durationoflabor,andApgarscoresweresimilarinthetwogroups.CONCLUSION:A10g/Lchl
5、oroprocaineand1.25g/Lropivacaineareclinicallyofsimilareffectsinlaboranalgesia.【Keywords】chloroprocaine;ropivacaine;epidural;patientcontrolledanalgesia;labor【摘要】目的：比较10g/L氯普鲁卡因与1.25g/L罗哌卡因用于硬膜外自控分娩镇痛的效果.方法：ASAⅠ~Ⅱ级的初产妇48例分为氯普鲁卡因和罗哌卡因两组(n=24)，在宫口开至2~3cm时给予镇痛液配方为10g/L氯普鲁卡因＋0.03g/L芬太尼或1.25g/L罗哌卡因＋0.03g/L
6、芬太尼的硬膜外自控分娩镇痛，至第二产程开始时停止.观察并记录镇痛前、给予硬膜外负荷量后5min,30min,宫口开全时的疼痛评分(VAS)和运动神经阻滞评分(MBS)以及各产程时间，新生儿出生后1min,5min的Apgar评分.结果：氯普鲁卡因组的疼痛评分较罗哌卡因组在给负荷量后5min低(P<0.01)，其余各时间点的疼痛评分均无差异.两组的运动神经阻滞评分、产程时间、新生儿出生后1min,5min的Apgar评分在各时间点均无统计学意义.结论：氯普鲁卡因10g/L与1.25g/L罗哌卡因的硬膜外分娩镇痛效果相当.【关键词】氯普鲁卡因；罗哌卡因；硬膜外；自控镇痛；分娩0引言氯普鲁卡因是酯类
7、局麻药，由于其具有起效快，麻醉效能强，停药后恢复快以及不易通过胎盘屏障等特点而被广泛应用于产科手术的麻醉.而罗哌卡因是长效局麻药，低浓度罗哌卡因有运动、感觉阻滞分离且毒性小的特点，是硬膜外无痛分娩较好的局麻药［1］.两种药物在硬膜外分娩镇痛中的应用效果尚缺乏对比性研究,为此我们观察如下.1对象和方法1.1对象200201/200406ASAⅠ~Ⅱ级拟经阴道分娩的初产妇48例，年龄23~30岁，孕足
