studies　on　partial　molar　volumes　of　some　amino　acids　and　their　groups　in　aqueous　solutions　from　293.15　k　to　333.15　k

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1、Studies　on　Partial　Molar　Volumes　of　Some　Amino　Acids　and　Their　Groups　in　Aqueous　Solutions　from　293.15　K　to　333.15　KChineseJ.Chem.Eng..12(4)521—526(2004)StudiesonPartialMolarVolumesofSomeAminoAcidsandTheirGroupsinAqueousSolutionsfrom293.15Kto333.15KZHAOChangwei(赵长伟),MAPeishe

2、ng(~沛生)andXIAShuqian(夏淑倩)SchoolofChemicalEngineeringandTechnologyTianjinUniversity,Tianjin300072,ChinaAbstractDensitiesofaqueoussolutionsofeightaminoacids,glycine,L—alanine,L—valine,L—isoleucine,L—serine,L—threonine,L—arginineandL.phenylalanine,aremeasuredasafunctionofaminoa

3、cidconcentrationfroln293.15Kto33315KThesedataareusedtocalculatetheapparentmolarvolumeandinfinitedilutionapparentmolarvolume(partialmolarvolume).Dataoffiveaminoacidsareusedtocorrelatepartialmolarvolumeusinggroupcontributionmethodtoestimatethecontributionsofthezwitterionicendg

4、roups(NH,COO一)andCH2group,oHgroup,CNHNHNH2groupandC6H5(pheny1)groupofaminoacidsTheresultsshowthatvaluesforallkindsofgroupsofaminoacidsstudiedincreasewithincreaseoftemperatureexceptthoseforCH2group,whicharealmostconstantwithinthestudiedtemperaturerange.Dataofotheraminoacids,L

5、—valine,L—isoleucineandL—threonine,arechosenforcomparisonwiththepredictedpartialmolarvolumeusingthegroupadditivityparametersobtained.Theresultsconfirmthatthisgroupadditivitymethodhasexcellentpredictiveutility.Keywordspartialmolarvolume,aminoacid,groupcontribution1INTRoDUCTIo

6、NDataonthethermodynamicandtransportprop—ertiesandtheinteractionofproteinsinaqueousphaseplayakeyroleintheoptimizationanddesignofboththecurrentlyusedandproposedindustrialprocessesofbiochemistry[-5}.Ontheotherhandaminoacidshavebeenquiteusefulasmodelsforunderstandingthethermodyn

7、amicbehaviorandthestateofsolva—tionofpeptidesandproteinsinsolution,especiallyinderivingsimpleadditivityschemesforthepredictionofpropertiesofbiochemica1systems[6一41.Volumetricpropertiesofsolute.suchaspartialmo—larvolumeareknowntobesensitivetothenatureofhydration.Furtherthehyd

8、rationeffectsareknowntobeverysensitivetotemperature.However,therearenotenou