阿奇霉素联合左氧氟沙星治疗社区获得性肺炎疗效研究

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1、阿奇霉素联合左氧氟沙星治疗社区获得性肺炎疗效研究【摘要】目的探讨阿奇霉素联合左氧氟沙星治疗社区获得性肺炎的疗效，为临床用药提供参考。方法将120例社区获得性肺炎随机分为3组，A组应用阿奇霉素治疗，B组应用左氧氟沙星治疗，C组联合应用阿奇霉素及左氧氟沙星治疗，疗程均为7~14d。观察3组患者临床疗效、病情变化、细菌清除率和不良反应。结果C组有效率为92.5%，与A组(62.5%)、B(67.5%)差异有统计学意义(P0.05)；A组与B组的临床疗效、病情变化、细菌清除率比较差异无统计学意义(P>0.05)。结论阿奇霉素联合左氧氟沙星治疗CAP患者，疗效高，病程短，副作用少，是基层医疗机

2、构CAP患者较为适宜的临床用药方案。【关键词】社区获得性肺炎；阿奇霉素；左氧氟沙星；临床观察ThecurativeeffectofAzithromycincombinedwithLevofloxacinthetreatmentofcommunityacquiredpneumoniaZHANGSheng-chao.XixiangPeople�sHospitalofBao’anDistrict,Shenzhen518102,China【Abstract】ObjectiveToexplorethecurative8effectofAzithromycincombinedwithLevofl

3、oxacinthetreatmentofcommunityacquiredpneumonia(CAP),toprovidebasisformedicationofcommunityacquiredpneumonia.Methods120CAPpatientsweredividedintothreegroupsrandomly.PatientsingroupAandBweretreatedwithAzithromycinandLevofloxacrespectively,andpatientsingroupCweretreatedwithAzithromycincombinedwith

4、Levofloxac.Curativeeffect,changesofpatient�scondition,clearancerateofbacterial,andadversereactionswereobserved.ResultsThecurativeeffectofgroupC(92.5%)hadbetterthanthepatientsingroupA(62.5%)andgroupB(67.5%).ThereweresignificantdifferencesbetweenthepatientsingroupCandthepatientsinothertwogroups,i

5、ntermsoffadetimeoffeverandrale,recoverytimeofroutinebloodtestandlungX-rayexamination,andclearancerateofbacterial.Therewerenosignificantdifferencesinadversereactionsrateamongthreegroups,andtherewerenosignificantdifferencesbetweenthepatientsingroupAandpatientsingroupBincurativeeffect,8changesofpa

6、tients’conditionandclearancerateofbacterial.ConclusionAzithromycincombinedwithLevofloxacinthetreatmentofCAPcanimprovecurativeeffect,cutdownthecourseofdisease,anddon�tincreaseadversereactions.It�sanappropriatetreatmentofCAPpatientsinprimaryhealthcaresector.【Keywords】communityacquiredpneumonia;Az

7、ithromycin;Levofloxac;Clinicalobservation社区获得性肺炎(communityacquiredpneumonia，CAP)是指在医院外罹患的感染性肺实质(含肺泡壁即广义上的肺间质)炎症，包括具有明确潜伏期的病原体感染而在入院后平均潜伏期内发病的肺炎［1］。CAP是常见的感染性疾病之一，由于社会人口老龄化加剧、免疫损害宿主增加、病原体变迁和抗生素耐药率上升等因素，CAP的发病率呈上升趋势，已成为威胁人群健康的重要疾病。而