阿奇霉素治疗社区获得性肺炎64例疗效分析

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1、·药物与临床·2013年11月第3卷第22期阿奇霉素治疗社区获得性肺炎64例疗效分析刘勇南京市鼓楼区大桥社区卫生服务站，江苏南京210015[摘要】目的探讨阿奇霉素治疗社区获得性肺炎的临床效果。方法将我中心收治的68例社区获得性肺炎患者，随机分为对照组和观察组。对照组采用头孢呋辛治疗，观察组采用阿奇霉素治疗。比较两组的治疗效果，治疗前后肺部指标改善情况及不良反应发生情况。结果对照组治疗总有效率79．4％，观察组总有效率97．1％。观察组总有效率显著高于对照组，差异有统计学意义(P

2、O．05o观察组胸部影像明显吸收时间、血常规恢复正常时间显著早于对照组，差异有统计学意义(P<0．05o对照组不良反应发生率为17．6％。观察组不良反应发生率14．7％。观察组与对照组不良反应发生率经统计学分析，差异无统计学意义(P>0．05o结论阿奇霉素治疗社区获得性肺炎疗效显著优于头孢呋辛，主要临床症状及生化指标改善情况优于头孢呋辛治疗，细菌学转归显著优于头孢呋辛，使用方便，不良反应少，值得临床推广应用。[关键词】阿奇霉素；头孢呋辛；社区获得性肺炎；治疗[中图分类号】R563．1[文献标识码】B[文章编号】2095—0616(2013)22—8O一03E

3、fficacyanalysisonazithromycininthetreatment0f64caseswithcommunityacquiredpneumoniaLIUYongDaqiaoCommunityHealthServiceStationofGulouDistrictinNanjingCity，Nanjing210015，China[Abstract]ObjectiveTostudytheclinicaleffectofazithromyeininthetreatmentofcommunityacquiredpneumonia．MethodsSix

4、ty-eightcaseswithcommunityacquiredpneumoniaadmittedinourcommunityhealthservicestationwererandomlydividedintothecontrolgroupandtheobservationgroup．Thepatientsinthecontrolgroupweretreatedwithcefuroxime，whilethepatientsintheobservationgroupweretreatedwithazithromycin．Thetreatmentefect

5、，improvementofpulmonaryindexesbeforeandafterthetreatmentandadversereactionsoftwogroupswerecompared．ResultsThetotalefectiverateofthecontrolgroupwas79．4％．whilethatoftheobservationgroupwas97．1％．Thetotalefectiverateoftheobservationgroupwassignificantlyhigherthanthatofthecontrolgroup．th

6、edifferencewasstatisticallysignificant<0．05)．Thefever．coughandsputumdisappeartimeoftheobservationgroupweresignificantlyearlierthanthoseofthecontrolgroup．thediferenceswerestatisticallysignificant(P<0．05)．Theobviousabsorptiontimeofchestimagingandbloodroutineexaminationrecoverytimeoft

7、heobservationgroupweresignificantlyearlierthanthatofthecontrolgroup．thedifferencewasstatisticallysignifieant(P<0．05)．Theincidenceofadversereactionsinthecontrolgroupwas17．6％．whilethatintheobservationgroupwas14．7％．Therewasnotsignificantdiferenceintheincidenceofadversereactionsbetween

8、thetwogroups(P>0．05)．Concl