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1、VⅢ因子相关抗原、基质金属蛋白酶9与米非司酮药物流产后子宫异常出血的相关性研究?222?生殖医学杂志2006年8月第15卷第4期VIII因子相关抗原,基质金属蛋白酶9与米非司酮药物流产后子宫异常出血的相关性研究郭晓霞,孙宁宁,史小林(首都医科大学生殖医学研究中心,北京100069)【摘要】目的探讨ⅥII因子相关抗原(VIII—RAg),基质金属蛋白酶9(MMP-9)与米非司酮药物流产(药流)后子宫异常出血的相关性.方法采用免疫组织化学法,对正常早孕人工流产(人流组),药流完全和不完全组蜕膜组织中ⅥII—RA
2、g和MMP-9进行标记,应用图像分析仪对标记结果进行定量观察,SPSS10.0统计软件进行数据分析.结果药流完全组和药流不全组出血区与人流组和药流不全组无出血区比较,蜕膜血管内皮细胞VIII-RAg和基质细胞MMP-9的表达,均有显着性差异(P<O.01),而药流完全组和药流不全组出血区之间,人流组和药流不全组无出血区之间无显着差异.结论米非司酮药流后子宫异常出血与蜕膜血管内皮ⅥII—RAg和基质细胞MMP一9的表达异常相关.【关键词】子宫异常出血;米非司酮;蜕膜;VIII因子相关抗原;基质金属蛋白酶
3、9【中图分类号]R169.42【文献标识码】A【文章编号]1004—3845(2006)04—0222—05CorrelationbetweenVIII—?RAgandMMP—?9inthedeciduaandabnormaluterinebleedingaftermifepristonemedicalabortionGUOXiao—xia,SUNNing—ning,SHIXiao—linCenterofReproductiveMedicine,CapitalUniversityofMedicalScien
4、ces,Beijing100069[Abstract]objective:ToinvestigatecorrelationbetweenfactorVIII—relatedantigen(VIII—RAg)andmatrixmetalloDroteinase9(MMP一9)inthedeciduaandabnormaluterinebleedingaftermifepristonemedicalabortion.Methods:Deciduatissueswereobtainedfromsixtyearly
5、pregnantwomenanddividedintothreegroups:surgicalevacuation,incompleteabortionandcompleteabortionaftermifepristonemedicalabortion.ImmunohistochemicaltechniqueswereusedtodetecttheexpressionofVIII—RAgandMMP一9inthesedeciduas.Quantitativeanalysiswasappliedtomeas
6、uretheexpressionoftwoproteins.Results:TheresultsshowedthatVIII—RAgimmunoreactivitywassignificantlylowerinthedeciduaofcompleteabortiongroupandinthebleedingareasofincompleteabortiongroupincomparisonwiththesurgicalevacuationgroupandthenonbleedingareasofincomp
7、leteabortiongroup(P<O.01).However,theexpressionofMMP一9wassignificantlyhigherinthecompleteabortiongroupandinthebleedingareasoftheincompleteabortiongroupwhencomparedwiththesurgicalevacuationgroupandthenonbleedingareasoftheincompleteabortiongroup(P<0.01
8、).Conclusions:TheabnormaluterinebleedingaftermifepristonemedicalabortionmightbeassociatedwiththedisregulationofVIII--RAgandMMP——9expressioninthedeciduawhichmayinducethecollapseofangiogenesisandmatrix,andleadt
