trodat-1脑多巴胺转运体spect显像

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1、TRODAT-1脑多巴胺转运体SPECT显像第27卷2006拒第4期7月中山大学(医学科学版)JOURNALOFSUNYAT-SENUNIVERSITY(MEDICALSCIENCES)V01.27No.4July2006肝豆状核变性患者99mTc—TRODAT一1脑多巴胺转运体SPECT显像王平,胡平,李洵桦,李爱萍(中山大学附属第一医院1.核医学科;2.神经内科,广东广州510080)摘要:【目的】研究肝豆状核变性rD)患者Tc—TRODAT一1脑多巴胺转运体(DAT)SPECT显像特点.【方法】WD患者31例,分为脑型组(18例)及非脑型组(13例).

2、所有WD患者及性别,年龄匹配正常对照者12例均行rc_TR0DAT一1脑DATSPECT显像,勾画出三组受检者脑内纹状体及小脑感兴趣区,计算机自动给出各区放射性计数,计算各组受检者纹状体区特异性放射性摄取比值(ST/CB,纹状体,小脑)并加以比较.【结果】脑型WD组,非脑型WD组及正常对照组ST,cB值分别为1.71±o.17,1.86±o.16,1.97~0.11:ST/CB值的组间比较均存在显着性差异(P-<0.001,P非-1

3、=o.036<0.05,P-

4、}----0.004<0.01);脑型WD患者及部分非脑型WD患者(5/13)

5、图像显示一侧或双侧纹状体的缩小及放射性摄取减少以后部为主,即相当于壳核区.【结论】rc—TRODAT一1SPECT脑DAT显像可敏感地反映脑型WD患者及部分非脑型WD患者黑质一纹状体多巴胺能神经元突触前DAT的功能状态,DAT功能降低以纹状体后部(即相当于壳核区)为主.关键词:rc-TRODAT一1;多巴胺转运体;肝豆状核变性;体层摄影术,发射型计算机,单光子中图分类号:R817.4文献标识码:A文章编号:1672—3554(2006)04—0463—04'Tc-TRODAT-1SPECTImagingofDopamineTransporterinPatie

6、ntswithWilsonDiseaseWANGPing,HUPing,LIXun-hua2,LIAi-ping~(1.DepartmentofNuclearMedicine,2.DepartmentofNeurology,TheFirstA~JliatodHospital,SUNYat-senUniversity,Guangzhou510080,China)Abstract..【Objective】Toinvestigatethecharacteristicsof~I'c-TRODAT-1SPECTimagingofdopaminetransporter(

7、DAT)inthepatientswithWilsondisease(wD).【Methods】DATimagingofSPECTwithrc—TRODAT-1wereperformedin18patientswithBrainWD,13patientswithNon-BrainWD,and12age—andgender-matchednormalvolunteers.Theregionsofinteresting(ROI)includingbilateralstriatum(ST)andcerebellum(CB)weredrawnmanually.Rad

8、ioactivitycountofeveryRO1wascalculatedbythecomputerautomatically.Specificstriatalbindingratios(withthecerebellumasthereferenceregion)werecalculatedandcomparedamongthethreegroups.【Results】ThemeanvaluesofST/CBwere1.71±0.17inBrainWD,1.86±0.16inNon-BrainWD,and1.97±0.11inNormalgroup,res

9、pectively.ThesignificantdifferencesofST/CBwerefoundamongBrain—WDcomparingwithNormalgroup(<0.001),Non—BrainWDcomparingtlINormalgroup(一&=0.036<0.05),andBrainWDcomparingwitlINon—BrainWD(N哪一&=0.OO4<0.01).In23patients(18ofBrainWD,5ofNon—BrainWD),therearpartofstriatumsho

10、wedmoreremarkabledeformati