资源描述：
《simulect和okt3诱导治疗应用于肾移植临床的疗效比较》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、Simulect和OKT3诱导治疗应用于肾移植临床的疗效比较第14卷第22期2004年11月中国现代医学杂志ChinaJournalofModemMedieineVo1.14No.22NOV.2似文章编号:1005-8982(2004)22—0009—03EffectofSimulectandOKT3inductiontherapy.altransplantatioinrenalolantation?论着?FANGZhen—qiang,ZHANGGen—fu',HUANGChi—bing,FANMing—qi(RendDiseasesResearchCe
2、nter,DepartmentofUrinarySurgery,XiruliaoHospital,ThirdMilitaryMedicalUniversity,Chongqing400037,P.R.China)Abstract:Objective:ToevaluatetheefficacyandsafetyofSimulectandOKT3inductiontherapyinrenaltransplantation.Methods:Onehundredandseventyrecipientswereretrospectivelyanalyzedandd
3、ividedintoSimulectgroupandOKT3group.Maintenanceimmunosuppressivetherapyregimenconsistedofprednisone,acrolimusorcyclosporineAandmycophenolatemofetilinallrecipients.Simulectgroupreceived2-doseSimulect(20mg)intravenousinfusion2hoursbeforeoperationandonpostoperativeday4.OKT3grouprece
4、ived0KT3(5mg/d)intravenousinfusionfrompostoperativedayltoday7or10.Acuterejection,delayedgraftfunction,sideef--fectsandsurvivalratesofgraftsandrecipientswithinlyearaftertransplantationwereobserved.Results:Duringafollow-uplyear6casesweresubjectedtoacuterejection(AR)inSimulectgroupa
5、nd28inOKT3group(P<0.05).InOKT3group5casesweresubjectedtosecondacuterejection,7casesofARrequiredATGtherapy.Theinci—dencesofdelayedgraftfunction,cytokinereleasesyndromeandallergicreactioninSimulectgroupweresignificandylowerthanthatinOKT3group(6VS32,0VS49,0VS31;P<0.01).Theinci
6、dencesofdelayedgraftfunction,cy-tokinereleasesyndromeandallergicreactioninSimulectgroupweresignificandylowerthanthatinOKT3group(6VS32,0VS49,0VS31;P<0.01).TheincidencesofinfectioninSimulectgroupwaslowerthanthatinOKT3groupfl6VS45;P<0.05).Conclusions:Simulectisasafeandeffectiv
7、einductiontherapeuticagentandcansubstituteforOKT3inrenaltransplantation.Keywords:Simulect;OKT3;kidneytransplantation;acuterejection;inductiontherapyCLCnumber:R699.2Documentcode:ASimulect和OKT3诱导治疗应用于肾移植临床的疗效比较方针强,张艮甫,黄赤兵,范明齐(第三军医大学新桥医院泌尿外科,全军肾脏病中心,重庆400037)摘要:目的评价Simulect和OKT3作为肾移
8、植诱导治疗的有效性和安全性.方法将170例首次肾移植受者随机分为两组:Simul
