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1、益气活血复方对自发性高血压大鼠左室心肌形态结构的影响张纯，陈利国，戴勇，胡小勤，郑佩娥【关键词】益气活血复方；,,自发性高血压大鼠；,,,左室肥厚；,,形态结构 摘要：目的探讨益气活血复方对自发性高血压大鼠（spontaneouslyhypertensiverats,SHR）左室肥厚(leftventricularhypertrophy,LVH)及左室心肌形态结构的影响。方法雄性14周龄SHR50只，随机分为复方高剂量组（SHRY1）、复方中剂量组（SHRY2）、复方低剂量组（SHRY3）、模型对照组（SHRC）、硝苯地平组（SHRX）。监测尾动脉收缩压（systolicbloodpress
2、ure,SBP），每4周1次，8周后取材。测算心脏重量指数（heartassindex,LVMI）；光镜、透射电镜观察左室心肌细胞形态结构的改变。结果（1）与SHRC组比较，灌胃4，8周后，各治疗组SBP显著降低（P＜0.01）；（2）与SHRC组比较，灌胃8周后，SHRY1、SHRY2及SHRX组HI均明显降低（P＜0.05或P＜0.01）；（3）光镜观察发现：SHRC组心肌纤维增粗或萎缩、断裂或排列紊乱，部分心肌细胞核肥大或固缩；透射电镜观察发现：SHRC组可见部分心肌细胞核膜皱缩，核染色质凝聚、趋边，偶见核固缩，部分心肌细胞线粒体明显肿胀。与SHRC组比较，SHRY1组上述病变明显减轻；
3、SHRY2、SHRX组病变有所改善；SHRY3组病变改善不明显。结论益气活血复方、硝苯地平均能降低SBP、HI，减缓SHR左室肥厚形成、发展过程中左室组织结构的破坏。 关键词：益气活血复方；自发性高血压大鼠；左室肥厚；形态结构 EffectsofYiqihuoxueDecoctionontheMorphologicalStructureofMyocardialCellsinLeftVentricleofSpontaneouslyHypertensiveRats Abstract：ObjectiveToexploretheeffectsofYiqihuoxuedecoctiononleft
4、ventricularhypertrophyandthemorphologicalstructureofmyocardialcellsinleftventricleofspontaneouslyhypertensiverats(SHR).MethodsFiftyfourteenaleSHRlyinto5groups:SHRY1(treatedoderatedoseofYiqihuoxuedecoction),SHRY3(treatedeasuredbeforeandduringtreatmenteveryfourent,allratsassindex(LVMI)orphologicalands
5、tructuralchangesofmyocardialcellsinleftventricleofSHRsicroscopeandtransmissionelectronmicroscope(TEM).Results(1)After4or8ent,paredeachtreatmentgroupent,paredSHRY1,SHRY2andSHRXicroscopeusclefibersent,asehypertrophicnuclearorpyknosisofmyocardialcells.TheresultsunderTEMeleftventriculartissuesobtainedfr
6、omSHRCgroup,nuclearmembraneshrankandnuclearchromatincondensedandcongregatedundernuclearmembranelikespeckle,abuttingagainstthenuclearenvelope;andpyknosisemyocardialcellsarkedlysedisorganizedordisruptedmitochondrialcristaeentionedpathologicalchangesofSHRY1elioratedslightlyinSHRY2andSHRX;butthereprovem
7、entinSHRY3.ConclusionYiqihuoxuedecoctionandnifedipinecanreducetheSBP,HIandsloagesofleftventricleinSHRsduringtheprocessofLVH. Keyl药液含2g生药）。硝苯地平，10mg/片（广东华南制药厂生产，批号：040602）。 1.2动物及分组清洁级雄性14周龄SHR大鼠50只，
