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1、NasalCholeraToxinElicitsIL【摘要】inthisstudy,ineucosaladjuvantcansupporttrinitrophenyl(tnp)-lps-specificmucosalimmuneresponses.c57bl/6miceucosaligaabresponsesaofmicegivennctplustnp-lpsthaninthosegiventnp-lpsalone.highnumbersoftnp-specificigaab-formingcellsucosaltissuessuchasthenasalpas
2、sages(nps),thesubmandibularglands(smgs),andnasopharyngeal-associatedlymphoreticulartissueofmicegivennct.floetricanalysisshobersofsurfaceiga+,cd5+bcells(b-1abcells)insmgsandnpsofmicegivennasaltnp-lpsplusnctthaninthosegiventnp-lpsalone.furthermore,increasedlevelsofil-5r-chaingsandnpso
3、fmicegivennasaltnp-lpsplusnct.thus,cd4+tcellsfromthesemucosaleffectorlymphoidtissuesproducehighlevelsofil-5atbothproteinandmrnalevels.iceab,significantreductionsintnp-specificmucosaligaabresponsesucosalimmuneresponsestoatcell-independentagduetothecross-talkbetucosaleffectorlymphoidt
4、issues.【关键词】receptorexpressingantibodyresponsesintroductionforeffectiveag-orpathogen-specificmucosalimmuneresponses,liveattenuatedviralorbacterialdeliverysystemsormucosaladjuvantsmustgenerallybeused.adjuvantsoffertheadvantageofelicitingmucosalasmuneresponses.abacterialenterotoxin,na
5、tivecholeratoxin(nct),3asutants(mutantcts(mcts)),areucosaladjuvantsfortheinductionofbothmucosalandsystemicimmunitytocoadministeredproteinags(1,2,3,4).mucosaladministrationofvaccinetogetherctsinducescd4+th2-typecellsaigg1,igg2b,ige,andiga,asucosalsecretory-iga(s-iga)abresponses(1,2,3
6、,4).nasaldeliveryofagplusamucosaladjuvanthasemergedasperhapsthemosteffectiveucosalimmunity,includingsalivarys-igaabresponses.again,moststudiescanbedividedintothosethatusesolublevaccineponentsucosaladjuvantssuchasnctandthosethatuseattenuatedbacterialandviralvectors,suchasrebinantsalm
7、onellaoradenovirusvectors,respectively.inthisregard,ithasbeenshomunizationctelicitedova-specifics-igaabresponsesinthesubmandibularglands(smgs)inadditiontoothermucosaleffectorlymphoidtissues(4,5).othershaveshoicegiventhenasal40-kdaoutermembraneproteinofporphyromonasgingivalisandnctas
8、mucosaladjuvantdisp
