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ID:58298280
大小:1.14 MB
页数:4页
时间:2020-05-03
《剪切波组织定量技术评估肝弹性硬度的多因素回归分析:初步临床研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中华超声影像学杂志2013年12月第22卷第12期ChinJUltrasonogr,December2013,Vol22,No.12.临床研究.剪切波组织定量技术评估肝弹性硬度的多因素回归分析:初步临床研究丁红马姣姣王文平毛枫徐晨黄备建【摘要】目的初步分析剪切波组织定量(elastographypointquantification,ElastPQ)技术评估肝弹性硬度的可行性及其主要影响因素。方法使用PhilipsiUElite超声仪对235例肝肿瘤患者的右叶肝实质进行弹性硬度检测,获得Elast
2、PQ值,与组织病理学的肝纤维化分级(s)、炎症程度(G)和脂肪变程度以及性别和年龄因素相比较,采用多重线性回归的逐步回归方法筛选出与ElastPQ弹性测值密切相关的因素,并获得拟合方程。结果ElastPQ弹性测值随着肝纤维化程度和炎症活动程度的加重而增大,两者相关性具有统计学意义(r=0.75,P=0.00;r=0.64,P=0.00);而脂肪变程度、性别和年龄因素与ElastPQ弹性测值无明显相关(P>0.05)。ElastPQ对肝纤维化程度和炎症活动程度的回归方程为:ElastPQ=1.205
3、S+1.075G+4.537。结论ElastPQ技术可有效检测肝组织弹性硬度,其中肝纤维化程度和炎症活动程度是ElastPQ弹性测值的主要影响因素。【关键词】超声检查;肝硬化;弹性;剪切波组织定量Apreliminaryclinicalstudyontheassessmentofliverfibrosisbyelastographypointquantificationtechniquewithmu
4、tivariateregressionanalysisDINGHong,MAJiao—jiao,W
5、ANGWen—ping,M_AOFeng,XUChen,HU_ANGBei—jian.DepartmentofUltrasound,ZhongshanHospital,FudanUniversity,Shanghai200032,ChinaC0rrs0dgauthor:WANGWen—ping,Email:puguang61@126.COWl[Abstract]0bjectiveTopreliminarilyevaluatethefeasibilityofelastographypointquan
6、tification(ElastPQ)technologyinthedeterminationofliverstiffnessaswellasitsimpactfactors.MethodsAmountto235patientswithliverneoplasmsunderwentliverstiffnessmeasurementintherightlobeofliverusinganultrasoundscanner(iUElite,Philips).ElastPQvalueswereobtai
7、nedandcomparedwiththeliverfibrosisstage(S),thegradeofnecroinflammatoryactivity(G)andsteatosisassessedhistologicallyaswellasgenderandage.ThefactorsrelatedtoElastPQvalueswereexploredbystepwiseregressioninmultiplelinearregressionanalysisandtheregressione
8、quationwasestablished.ResultsInthemultiplelinearregressionmodelofElastPQvalues.1iverfibrosisandnecroinflammatoryactivitywereassociatedwithElastPQ(P<0.05)whileotherfactorsincludingage,genderandhepaticsteatosishadnoeffectonElastPQstatistically(P>0.05).T
9、heequationoflinearregressionwasElastPQ=1.205S+1.075G+4.537.ConclusionsElastPQtechniqueisareliablynoninvasivetoolintheliverstiffnessmeasurement.LiverfibrosisandnecroinflammatoryactivityarethemainfactorsaffectingliverstiffnessmeasuredbyElastPQ.[
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