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1、百令片治疗糖尿病早期肾病疗效观察［摘要］目的口11估百令片治疗糖尿病早期肾病的疗效。方法选择该院门诊或住院的2型糖尿病早期肾病患者102例，随机分为治疗组与对照组，两组均为51例。两组患者均给予糖尿病饮食及常规治疗，治疗组额外予百令片6片（2.7g）,3次/d,口服，16周为1疗程。用药前后测定患者的尿微量白蛋白/肌酎、血甘油三酯、低密度脂蛋白、空腹血糖、血肌酎含量及超敏CRP、GFR、TNF-a、TGFB等指标。比较这些指标治疗前后的差异。结果治疗组经治疗后超敏CRP、尿微量白蛋白/肌酢明显下降，与对照组比较差异有统计学意义（P0.0
2、5）,两组治疗后比较差异无统计学意义（P>0.05）；两组治疗后低密度脂蛋白胆固醇、甘油三酯均较治疗前差异有统计学意义（P0.05）o两组治疗后GFR、血清炎症标志物TNF-a和纤维化标志物TGF8水平均得到改善。结论百令片能明显减少糖尿病早期肾病患者的血肌酎、超敏CRP、尿微量白蛋白/肌酎、GFR、TNF-a；对早期糖尿病肾病有较好的辅助治疗作用。［关键词］糖尿病肾病；百令片；微量白蛋白尿；C反应蛋白［中图分类号］R692［文献标识码］A［文章编号］1672-4062(2017)02(b)-0010-04ObservationonCu
3、rativeEffectofBailingTabletsinTreatmentofEarlyDiabeticNephropathyZHOUQiangl,SHAOYi-chuanl,GANZheng-qi1,GUORu-yal,FANGLi-shul,ZHANGLu-yan21.EndocrinologyDepartment,JiaxingFirstHospital,Jiaxing,ZhejiangProvince,314001China；2.DepartmentofOphthalmology,JiaxingFirstHospital,J
4、iaxing,ZhejiangProvince,314001China[Abstract]ObjectiveToevaluatethecurativeeffectofBailingTabletsintreatmentofearlydiabeticnephropathy.Methods102casesofpatientswithearlytypeIIdiabeticnephropathywererandomlydividedintotwogroupswith51casesineach,bothgroupsweregiventhediabe
5、tesdietingandroutinetreatment,thetreatmentgroupaddedtheadditionalsixbailingtablets,threetimesperday,oral,16weekswereatreatmentcourse,beforeandaftermedication,themicroalbuminuria/creatinine,bloodtriglyceride,lowdensitylipoprotein,fastingbloodglucose,serumcreatininecontent
6、andhypersensitivityCRP、GFR、TNF-a、TGFBofpatientsweremeasured,andthedifferencesbeforeandaftertreatmentwerecompared.ResultsAftertreatment,thehypersensitivityCRPandmicroalbuminuriaobviouslydecreasedinthetreatmentgroup(PO.05),andtherewerenoobviousdifferencesbetweenthetwogroup
7、saftertreatment(P>0.05),aftertreatment,thedifferencesinthelowdensitylipoproteincholesterinandtriglyceridebeforeandaftertreatmentwerestatisticallysignificant(PO.05),aftertreatment,theGFR,seruminflammatorymarkerTNF-aandfibrosismarkerTGFBlevelwereimprovedinthetwogroups.Conc
8、lusionThebailingtabletscanobviouslydecreasetheserumcreatinine,hypersensitivityCRP,microalbuminuria/crea
