正文描述:《痛风患者血浆非高密度脂蛋白胆固醇和同型半胱氨酸水平变化及临床意义.doc》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、III痛风患者血浆非高密度脂蛋白胆固醇和同型半胱氨酸水平变化及临床意义蒋兴亮I李敏2,周京国2气杨其彬之(1.川北医学院附属医院检验科,南充637000:2.川北医学院附属医院风湿免疫研究所,南充637000)摘要:目的探讨血浆非高密度脂蛋白胆固醇(non-HDL-C)和同型半胱氨酸(Hey)水平在痛风患者中变化及临床意义。方法选取51例痛风患者及40例正常体检者,分别测定血浆甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL.C)、低密度脂蛋白胆固醇(LDL.C)和Hey,通过Frost法计算出非高密度脂蛋白胆固醇含量。分析n
2、on-HDL-C及Hey与其他血脂指标间的相关关系。结果痛风患者non・HDL・C和Hey水平分别为(3.63±0.91)mmol/L,(12.9±3.9)pmol/L,均较对照组显著升高[(3.11±0.70)mmol/L,PvO.Ol),(10.1±3.7
3、imol/L,P<0.01)]o相关分析显示,non-HDL-C与Hey无相关关系,LDL.C与non-HDL-C呈高度正相关(E).711,PvO.Ol),Hey与其他血脂间无相关关系。结论血浆non-HDL-C及Hey水平在痛风患者中显著增加,血浆non-HDL和Hey增高可能是
4、痛风患者易发心血管疾病的重要危险因素。关键词:非高密度脂蛋白胆固醇;同型半胱氨峻;痛风Theclinicalsignificanceofplasmanon-high-densitylipoproteincholesterolandhomocysteinelevelinpatietswithgoutJIANGXing-liang,LIMin2,ZhOUJing-guo2,etal,(1.InstituteofRheumatologyandImmunology,AffiliatedHospitalofNorthSichuanMedicalCol
5、lege,Nanchong,637000,China.2.DepartmentofClinicalLaboratory,AffiliatedHospitalofNorthSichuanMedicalCollege,Ncmchong,637000,China).Abstract:ObjectiveToinvestigatethechangeandclinicalsignificanceofplasmanon-high-densitylipoproteincholesterol(non-HDL-C)andhomocysteine(Hey)lev
6、elinpaticnswithgout.MethodsThetriglyceride(TG),totalcholesterol(TC),highdensitylipoproteincholesterol(HDL-C),lowdensitylipoproteincholesterol(LDL-C)andHeylevelin51goutand40healthyindividualsweredetermined.Non-HDL-CwascalcularedbyFrostmethod.Therelationsbetweennon-HDL-C,Hey
7、andbloodlipidswereanalyzed.ResultsTheresultsrevealedthatgoutypatientsexhibitedsignificantlygreaterplasmaHeylevels[(12.9±3.9)gmol/L]andnon-HDL-C[(3.63±0.91)mmol/L]levelthanhealthycontrolsdid(10.1±3.7gmol/L,△通讯作者PvO.Ol),(3.11±0.70mmol/L,PvO.Ol)].Theanalysisoflinearcorrelatio
8、nshowedtherewasnorelationshipbetweenplasmnon-HDL-CandHey(r=0.252,P>0.05),non-HDL-ClevelwassignificantlycorrelationwithlevelofLDL-C(r=0.711,PvO.Ol),therewasnorelationshipbetweenplasmHeyandlipidsingoutpatients.ConclusionPlasmanon-HDL-CandHeylevelwassignificantlyincreasedingo
9、utpatients.Plasmanon-HDLandHeymayplayanimportantroleinthepathogenesisofgoutwithcardiovasc
显示全部收起