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ID:55657821
大小:1.45 MB
页数:3页
时间:2020-05-23
《黄芩苷对肝癌细胞株SMMC-7721裸鼠移植瘤生长抑制作用及其机制.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、256董明,等黄芩苷对肝癌细胞株SMMC一7721裸鼠移植瘤生长抑制作用及其机铜黄芩苷对肝癌细胞株SMMC一7721裸鼠移植瘤生长抑制作用及其机制董明,侯俊明,高美花,魏辉ExperimentalstudyontheefectofBaicalinonCyclinD1andCaspase一3activityofhumanhepatocellularcarcinomaSMMC一7721celinnudemiceDongMing,HouJunming,GaoMeihua~,WeiHui、AfiliatedHospimlofShaan
2、xiUniversity。fChineseMedicine,ShaanxiXⅫ1712000,ChinaAffiliatedHospitalofYanbianUniversity,问inYanbian133000,China【Abstract】Objective:TotesttheefectofBaicalinongrowthoftransplantationtmnorusingtheSMMC一7721ani—malmodelinnudemicebearinghmnanhepatocellularcarcinonlacelll
3、ineMethods:BALB/cnudemicewereinjee—tedsubcutaneouslywithhmnanhepatolnacellineSMMC一77215×10/mlforduplicatetmnormodel20transplan—tednudemicewererandomlydividedintoblankcontrolgroupatdbaicalingroup,10ratsineachgroupThecontrolgroupwasgivennorlnalsalinebyintraperitoneali
4、njectionof10nfl/kg,Baicalinintraperitonealinjectionof100mkg,every2dinterlnitentdosingweightafter8tilnes,puttmnorweig,cancerinhibitionratetmnorCyclinD1andtheex—pressionofCaspase一3levelswerel~leasHredbyilnlnunohistochelnistryResults:Baicalin100mkgofthedorsmnSMMC一7721s
5、olidtmnoroflivercancerinhibitionratewas308%.theindexofliverandkidney.betweenthetwogroupswassimilar(P>005),thesuppressionofCyclinD1expressionandraisedintheexpressionofCaspase一3(P<005)Condusion:BaicalininhumanliverSMMC一7721ofthedorsmnsubcutaneoustransplantationtmnorgr
6、owthinhibition,itsefectsmaycutCyclinD1expressionthroughorincreasetheexpressionofCaspase一3occlusiontoin—hibitproliferationandpromotingthefunctionofapoptosisintheprotectionofLllcorgansfunction.baicalinhasnoobviousadvantageBaicalinmaybecomeoneoftheefectivetreatlnentfnp
7、rimaryhepatocelularcarcinonlafHCC)【Keywords】Baicalin;humanhepatolnacellineSMMC一7721;CyclinD1;Caspase一3ModernOncology2014,22(02):0256—0258【摘要】目的:以裸鼠人肝癌细胞株SMMC一7721移植瘤动物模型为研究对象,观察黄芩苷对移植瘤生长能力的影响,初步探讨黄芩苷对CyclinD1和Caspase一3表达的影响。方法:BALB/c裸鼠右前腋部皮下接种人肝癌SMMC一7721细胞5×10个,建立人
8、肝癌实体瘤模型。将20只成瘤裸小鼠随机分为空白对照组与黄芩苷组,每组l0只。对照组腹腔注射生理盐水10ml/kg,黄芩苷组腹腔注射黄芩苷注射液lOOmkg,每2d给药1次,间断给药8次后称体重、处死,瘤块离体称重,计算抑瘤率;用免疫组织化学方法检测实验组和对照组移植瘤中Cyc
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