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时间:2020-05-22
《鼻咽癌组织中CCR7和CXCR4的表达及其临床意义-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、HainanMedJ,Jun.2014,Vo1.25,No.11海南医学2014年6B第25卷第l1期doi:lO.3969/j.issn.1003—6350.2014.11.0609鼻咽癌组织中CCR7和CXCR4的表达及其临床意义郑大勇,董少婷,陈锦章,吕成伟,黄振华,黄娜,石敏(南方医科大学南方医院肿瘤内科,广东广州510515)【摘要】目的探讨CXC族趋化因子受体4(CXCR4)和CC族趋化因子受体7(CCR7)在鼻咽癌(NPC)组织中的表达及其临床意义。方法随机选择2012年1月至2013年1O月本院NPC患者60例,取其鼻咽癌组织(病例组)
2、,选择同期鼻咽部炎症患者30例,取其鼻咽部组织(对照组),采用免疫组织化学检测两组患者的CXCR4和CCR7表达情况。结果病例组CCR7和CXCR4的阳性表达分别为32例和27例,均高于对照组的6例和4例,其差异均有统计学意义(P<0.05),m期+Ⅳ期患者的CCR7和CXCR4阳性例数为22例和16例,高于I期+Ⅱ期的lO例和l1例,其差异均具有统计学意义(P<0.05);M。期CCR7阳性例数为24例,高于M0期的8例,差异也具有统计学意义(P3、异也具有统计学意义(尸4、Shao-ting,CHENJin-zhang,LVCheng—wei,HUANGZhen—hua,HUANG№SHIMin.DepartmentofInternalMedicine,SouthernMedicalUnwe~itySouthernHo~iml,Guangzhou510515,Guangdong,CHINA【Abstract】ObjectiveToexploretheexpressionofCXCchemokinereceptor-4(CXCR4)andCCchemo—kinereceptor-7(CCR7)innasopharyngea5、lcarcinoma(NPC)anditsclinicalsignificance.MethodsSixtypatientswithNPCadmittedinourhospitalfromJanuary2012toOctober2013wererandomlyselectedforNPCtissue,whichwasassignedasthediseasegroup.Another30caseswithnasopharyngealinflammationwereselectedascon-trolgroupfornormalnasopharyngeal6、tissue.CXCR4andCCR7intwogroupsweredetectedwithexpressionbyim—munohistochemistry.ResultsThepositiveexpressioncasesofCCR7andCXCR4inthediseasegroupwere32casesand27casesrespectively,whichwerehigherthanthoseinthecontrolgroupwith6casesand4cases,andtherewerestatisticallysignificantdife7、rentfP8、ith8cases,andthediferencewasstatisticallysignif
3、异也具有统计学意义(尸4、Shao-ting,CHENJin-zhang,LVCheng—wei,HUANGZhen—hua,HUANG№SHIMin.DepartmentofInternalMedicine,SouthernMedicalUnwe~itySouthernHo~iml,Guangzhou510515,Guangdong,CHINA【Abstract】ObjectiveToexploretheexpressionofCXCchemokinereceptor-4(CXCR4)andCCchemo—kinereceptor-7(CCR7)innasopharyngea5、lcarcinoma(NPC)anditsclinicalsignificance.MethodsSixtypatientswithNPCadmittedinourhospitalfromJanuary2012toOctober2013wererandomlyselectedforNPCtissue,whichwasassignedasthediseasegroup.Another30caseswithnasopharyngealinflammationwereselectedascon-trolgroupfornormalnasopharyngeal6、tissue.CXCR4andCCR7intwogroupsweredetectedwithexpressionbyim—munohistochemistry.ResultsThepositiveexpressioncasesofCCR7andCXCR4inthediseasegroupwere32casesand27casesrespectively,whichwerehigherthanthoseinthecontrolgroupwith6casesand4cases,andtherewerestatisticallysignificantdife7、rentfP8、ith8cases,andthediferencewasstatisticallysignif
4、Shao-ting,CHENJin-zhang,LVCheng—wei,HUANGZhen—hua,HUANG№SHIMin.DepartmentofInternalMedicine,SouthernMedicalUnwe~itySouthernHo~iml,Guangzhou510515,Guangdong,CHINA【Abstract】ObjectiveToexploretheexpressionofCXCchemokinereceptor-4(CXCR4)andCCchemo—kinereceptor-7(CCR7)innasopharyngea
5、lcarcinoma(NPC)anditsclinicalsignificance.MethodsSixtypatientswithNPCadmittedinourhospitalfromJanuary2012toOctober2013wererandomlyselectedforNPCtissue,whichwasassignedasthediseasegroup.Another30caseswithnasopharyngealinflammationwereselectedascon-trolgroupfornormalnasopharyngeal
6、tissue.CXCR4andCCR7intwogroupsweredetectedwithexpressionbyim—munohistochemistry.ResultsThepositiveexpressioncasesofCCR7andCXCR4inthediseasegroupwere32casesand27casesrespectively,whichwerehigherthanthoseinthecontrolgroupwith6casesand4cases,andtherewerestatisticallysignificantdife
7、rentfP8、ith8cases,andthediferencewasstatisticallysignif
8、ith8cases,andthediferencewasstatisticallysignif
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