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时间:2020-05-07
《多肿瘤标志物联合应用对肝癌的诊断价值-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、第31卷第5期新乡医学院学报V01.31No.5·388·2o14年5月JournalofXinxiangMedicalUniversityMav20141。。◆。。·。◆。·。。◆。’·。。◆。。·。。◆。。◆。。◆。。◆。。·。。◆。。·。。◆。◆。。◆。。◆。0◆o0◆。。●o0◆。。●00●。o◆。。●。。◆。。·。。◆。。◆。。◆o。·。。◆。o·。。!本文引用:郑阳,陈涛.多肿瘤标志物联合应用对肝癌的诊断价值[J].新乡医学院学报,2014,31(5):388-390.i【临床研究】●
2、r0◆00●oo◆oo●00◆oo◆00●oo◆00◆oo◆00◆0o●00●oo●00◆00●00●00●oo◆00◆00◆00●oo●00◆oo●o0●00●0o●00●00●00●00◆oo●00◆00●00◆多肿瘤标志物联合应用对肝癌的诊断价值郑阳,陈涛(辽宁省肿瘤医院检验科,辽宁沈阳110042)摘要:目的探讨多肿瘤标志物联合应用对肝癌的诊断价值。方法选择156例肝癌患者(肝癌组)、148例肝炎患者(肝炎组)及120例同期健康体检者(对照组)作为研究对象,对肝癌组、肝炎组及对照组受试者的
3、甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原199(CA199)、—L一岩藻糖苷(AFU)等4种肿瘤标志物进行检测,比较其血清水平及异常率。结果肝癌组患者血清AFP、CEA、CA199和AFU水平和异常率均显著高于肝炎组和对照组,差异有统计学意义(P<0.05);原发性肝癌患者血清AFP和AFU的水平高于转移性肝癌患者,血清CEA水平低于转移性肝癌患者,差异均有统计学意义(P<0.05);AFP、CEA、CA199和AFU联合检测对肝癌诊断灵敏度为87.4%。结论AFP、CEA、CA199和A
4、FU联合检测有利于肝癌的筛查。关键词:甲胎蛋白;癌胚抗原;糖类抗原199;—L.岩藻糖苷;肝癌中图分类号:R735.7文献标志码:A文章编号:1004-7239(2014)05—0388—03Clinicalvalueanalysisofmulti—tumormarkersfordiagnosisoflivercancerZHENGYang.CHENTao(DepartmentofClinicalLaboratory,LiaoningCancerHospital&Institute,Shenyan
5、g110042,LiaoningProvince,China)Abstract:ObjectiveToinvestigatetheclinicalvalueofmulti—tumormarkersfordiagnosisoflivercancer.MethodsOnehundredandfifty—sixcasesoflivercancerpatients,148casesofhepatitisand120casesofhealthyexaminationpersonsweretakenasres
6、earchsubjectstodetecttheiralphafetoprotein(AFP),carcinoembryonicantigen(CEA),carbohydrateantigen199(CA199)and01.L—fucosidase(AFU)inlivercancerrespectively.Theseiumlevelsandtheabnormalratesofthemwerecompared.ResultsThelevelsofAFP,CEA,CA199,AFUandtheabn
7、ormalratesoftheminlivercancergroupwerehigherthanthoseinhepatitisgroupandcontrolgroup,thedifferenceswerestatisticallysignificant(P<0.05).AFPandAFUserumlevelsinprimaryhepaticearcinomapatientswerehigherwhileselqlmCEAleve1.inthemwaslowerthanmetastatichepa
8、ticcar—cinomapatients,thedifferenceswerestatisticallysignificant(P<0.05).ThesensitivitydegreeofcombineddetectionofAFP,CEA,CA199andAFUforlivercancerdiagnosticwas87.4%.ConclusionCombineddetectionofAFP,CEA.CA199andAFUisbeneficialforlivercancerscr
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