欢迎来到天天文库
浏览记录
ID:54981794
大小:260.19 KB
页数:3页
时间:2020-05-07
《乙型肝炎病毒感染者肝组织IL-12表达及其意义-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·424·实用肝脏病杂志2013年10月第16卷第5期JClinHepatol,Oct.2013.Vo1.16No.5·乙型肝炎·乙型肝炎病毒感染者肝组织IL一12表达及其意义沫郜玉峰汤磊戴金津邹桂舟李旭【摘要】目的探讨乙型肝炎病毒感染者肝组织白细胞介素12(IL-12)表达与临床表现和肝脏病理学变化的关系。方法应用免疫组化法检测9例正常肝脏组织、183例慢性乙型肝炎(CHB)、41例乙型肝炎肝硬化、37例HBV相关肝癌患者肝组织IL一12表达情况,并与临床特点和病理分级等进行相关性分析。结果CHB患者肝组织IL_12以弱阳性表达为主,阳性和强阳性表达的比例仅为26.8%,而肝硬化和肝癌患
2、者阳性和强阳性表达的比例分别为36.6%和48.6%,均显著高于CHB患者(P<0.05);HBeAg阴转且HBVDNA阴转的CHB患者肝内IL一12阳性表达比例为64.3%,显著高于HBeAg阳性伴肝功能异常者(30.0%)和肝功能正常者(20.4%)(P<0.05);未发现IL—l2表达与肝脏炎症分级或纤维化分期具有相关性。结论IL一12可能参与HBV感染后的疾病进展与转归。【关键词】慢性乙型肝炎;肝细胞癌;肝硬化;白细胞介素12;免疫组化doi:10.3969~.issn.1672—5069.2013.05.013Theexpressionofinterleukin—‘12andit
3、sclinicalsignificanceinlivertissuesofpatientswithhepatitisBvirusinfectionGaoYufeng,TangLei,DaiJinjin,eta1.DepartmentofLiverDiseases,TheSecondHaspital,Affiliat—edtoAnhuiMedicalUniversity,Hefei230601,AnhuiProvince,China【Abstract】objectiveToinvestigatetherelationshipbetweeninterleukin一12(IL一12)expres
4、sioninlivertis—suesandtheclinicalsignificanceinpatientswithhepatitisBvirusinfection—associatedliverdiseases.MethodsIL一12expressioninthelivertissuesof183patientswithCHB,41patientswithlivercirrhosisand37patientswithHCCwasdetectedbyimmunohistochemicalstaining;ThecorrelationofIL-12expressiontoclinical
5、featuresandpathologicalgradingandstagingwasanalyzed.ResultsIL-12expressionwasmildpositiveinlivertissuesfromCHBpatients,butwasmuchs~ongerincirrhoticandHCCpatients;ThepositiveandstrongpositiveratesofIL一12expressioninpatientswithcirhosisandwithHCCwere36.6%and48.6%,respectively,significantlyhigherthan
6、thatinCHBpatients(26.8%,P<0.05);ThepositiverateofIL-12inCHBpatientswithHBeAgnegativeandHBVDNAlosswas64-3%.significantlyhigherthanthatinCHBpatientswithHbeAgpositiveandHBVDNApositive(30.0%,P<0.05);TherewasnocorelationbetweentheexpressionofIL一12andliverinflammationgradingandfi—brosisstaging.Conclusio
7、nsIL一12maybeinvolvedinthediseaseprogressionandoutcomeofpatientswithchronichepatitisBviralinfection.【Keywords】HepatitisB;Hepatocellularcarcinoma;Cirhosis;Interleukin-12;Immunohistochemicalstaining病毒持续复制和机体免疫清除反应是慢
此文档下载收益归作者所有