微生态制剂对慢性肝衰竭患者肠道菌群的影响-论文.pdf

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1、中国微生态学杂志2013年12月第25卷第12期ChineseJournal0fMicroecology，Dec．2013，V01．25No．121415·临床研究·微生态制剂对慢性肝衰竭患者肠道菌群的影响葛金华，曾祥铨，连豫苞福建医科大学附属三明市第一医院感染科，福建三明365000摘要：目的探讨微生态调节剂双歧杆菌三联活菌对慢性肝衰竭患者肠道菌群的影响。方法根据治疗方法不同将46例慢性肝衰竭患者随机分为治疗组和对照组各23例，两组均给予慢性肝衰竭常规治疗，治疗组在上述基础上给予双歧杆菌三联活菌胶囊，210ms／粒，每次2粒，

2、2次／d，疗程2周。观察治疗前后两组患者的肠道菌群菌落计数变化及血清总胆红素(TBiL)、凝血酶原时间(P，I1)变化。结果两组患者在实验前肠道菌群、TBiL、PT比较差异均无统计学意义(P>0．05)。治疗2周后，对照组患者治疗前后肠道菌群无明显变化(P>0．05)，TBiL、PT有所下降但不显著，治疗组患者的肠球菌、双歧杆菌、乳杆菌以及酵母样真菌的菌落数均较治疗前明显增加，TBiL、PT较前明显好转(P<0．05)。结论口服双歧杆菌三联活菌制剂可以促进慢性肝衰竭患者肠道正常菌群的恢复及改善肝功能。关键词：微生态制剂；慢性肝衰

3、竭；肠道菌群中图分类号：R378文献标识码：A文章编号：1005-376X(2013)12．1415-04TheinfluenceofprobiotictotheintestinalflorainpatientswithchronicliverfailureGEJin．hua．ZENGXiang—quan．LIANYu—baoTheFirstHospitalofSanmingtoAffiliatedFujianMedicalUniversity，Sanming365000，ChinaAbstract：ObjectiveTodis

4、cusstheinfluenceofprobiotictotheintestinalflorainpatientswithchronicliverfail—ure．MethodsAccordingtothediferenttreatmentmethods46patientswererandomlydividedintotreatmentgroupandcontrolgroup．Eachgrouphad23cases．Controlgroupwasgiventhetherapiessuchasonventionalprotecti

5、ngliver，nutritionalsuppo~，dieresisandsomesymptomatictreatments．TreatmentgroupwasgivenBifdTripleViableCapsulesbasedonthetreatmentofcontrolgroup．Thechargesofcolonycountofintestinalfloraoftwogroupsbeforeandaftertreatmentwereobsmwed，TBilandPToftwogroupsbeforeandaftertrea

6、tmentwerecomparedandana—lyzed．ResultsTherewerenosignificantdifferenceinintestinalflora，TBilandPTbetweentwogroups(P>0．05)．Therewasnoobviouschargeofintestinalfloraincontrolgroupaftertreatmentof2weeks(P>0．05)．TBilandPTalldecreasedwithoutsignificantdifference(P>0．05)．The

7、colonycountofEnterococcus，Bifidobacte—rium，Lactobacillusintreatmentgroupwereincreasedobviouslyandthecolonyofyeast—likefungicoloniesintreat—mentgroupshowedsignificantlylowerthanthecontrolgroup(P<0．05)；TBilandPToftreatmentgroupwerede—creasedobviouslywhichcomparedwithth

8、econtrolgroup(P<0．05)．ConclusionBifldTripleViableCapsulescanpromotetherecoveryofnormalfloraofpatientswithchronicliverfailure，andimp