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《声触诊组织量化技术对肝纤维化的诊断价值-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·14·中国现代医药杂志2013年11月第15卷第11期MMJC,Nov2013,Vol15,No.11声触诊组织量化技术对肝纤维化的诊断价值包作伟童学成张伟民【摘要】目的评估声触诊组织量化(VTQ)技术对肝纤维化的诊断价值。方法选取2011年6月~2012年12月来我院就诊的慢性肝炎患者(慢性肝炎组)60例、肝硬化患者(肝硬化组)45例及健康体检者(健康对照组)25例,利用VTQ技术测定右肝感兴趣区肝脏横向剪切波速度(swv);慢性肝炎患者同期行肝穿刺活检病理检查,分析SWV与肝纤维化程度的相关性
2、,采用受试者工作特征(ROC)曲线,评价VTQ技术诊断肝纤维化的准确性。结果健康对照组、慢性肝炎组及肝硬化组肝脏SWV分别为(2.0~0.2)m/s、(2.3+0.4)m/s和(3.1~0.5)m/s,3者间具有显著性差异(P<0.05)。随着肝纤维化程度加深,肝脏SWV增高,SWV值与肝纤维化分期呈正相关,相关系数为0.73(P3、76。结论VTQ技术对肝纤维化具有较高的诊断价值。I关键词】声触诊组织量化技术肝纤维化DiagnosticvalueofvirtualtouchtissuesquantificationforHverfibrosisBaoZuowei,Xuecheng,ZhangWeimin.TheThirdPeople’HospitalofChangzhou,Changzhou213001【Abstract】ObjectiveToinvestigatethediagnosticvalueofvirtualtouc4、htissuesquantification(VTQ)intheassess—mentofliverfibrosis.MethodsFromJun2011toDec2012.VTQwasperformedin60caseswithchronichepatitis。45eas.eswithlivercirrhosisand25healthypersons,andtheshearwavevelocity(SWV)wasmeasuredinregionsofinterestoftherighthepati5、clobe.Thepatientswithchronichepatitisunderwentliverbiopsy.TherelationshipbetweenSWVandliverfibrosisgradewasanalyzed,andtheaccuracyofVTQindiagnosisingliverfibrosiswasevaluatedbyreceiveroperatingharacteristiccurve(ROCcurve).ResultsThevaluesofSWVinhealthy6、persons,patientswithchronichepatitisandlivercirhosiswere(2.0~0.2)rrds,(2.3+0.4)m/sand(3.1±O.5)m/s,respectively.Thereweresignificantdiferenceamongthethreegroups(P<0.05).TheSWVvaluesincreasedastheseverityofliverfibrosisprogressed,andwereassociatedwithliv7、erfibrosisgrade(r=0.73,P<0.05).TheareasundertheROCCurveswere0.94forS2and0.92forS3;thecut-ofvalueswere1.36m/sforS2(sensitivi·ty0.88%,specificity0.88%)and1.69m/sforS3(sensitivity0.92,specificity0.76).ConclusionTheVTQtechniquehasimportantvalueondiagnosing8、liverfibrosis.【Keywords】VirtualtouchtissuesquantificationLiverfibrosis早期准确判断肝脏纤维化程度.并采取积极有硬化患者肝脏SWV并结合病理学检查,评价VTQ效的治疗措施.可延缓疾病进展,减少肝硬化及其并技术对肝脏纤维化临床诊断价值。发症的发生。肝活检病理学检查是目前评价肝纤维化的金标准.但因其有创性往往难以被患者接受。声1材料与方法触诊组织量化(virtualtouchtissuequantific
3、76。结论VTQ技术对肝纤维化具有较高的诊断价值。I关键词】声触诊组织量化技术肝纤维化DiagnosticvalueofvirtualtouchtissuesquantificationforHverfibrosisBaoZuowei,Xuecheng,ZhangWeimin.TheThirdPeople’HospitalofChangzhou,Changzhou213001【Abstract】ObjectiveToinvestigatethediagnosticvalueofvirtualtouc
4、htissuesquantification(VTQ)intheassess—mentofliverfibrosis.MethodsFromJun2011toDec2012.VTQwasperformedin60caseswithchronichepatitis。45eas.eswithlivercirrhosisand25healthypersons,andtheshearwavevelocity(SWV)wasmeasuredinregionsofinterestoftherighthepati
5、clobe.Thepatientswithchronichepatitisunderwentliverbiopsy.TherelationshipbetweenSWVandliverfibrosisgradewasanalyzed,andtheaccuracyofVTQindiagnosisingliverfibrosiswasevaluatedbyreceiveroperatingharacteristiccurve(ROCcurve).ResultsThevaluesofSWVinhealthy
6、persons,patientswithchronichepatitisandlivercirhosiswere(2.0~0.2)rrds,(2.3+0.4)m/sand(3.1±O.5)m/s,respectively.Thereweresignificantdiferenceamongthethreegroups(P<0.05).TheSWVvaluesincreasedastheseverityofliverfibrosisprogressed,andwereassociatedwithliv
7、erfibrosisgrade(r=0.73,P<0.05).TheareasundertheROCCurveswere0.94forS2and0.92forS3;thecut-ofvalueswere1.36m/sforS2(sensitivi·ty0.88%,specificity0.88%)and1.69m/sforS3(sensitivity0.92,specificity0.76).ConclusionTheVTQtechniquehasimportantvalueondiagnosing
8、liverfibrosis.【Keywords】VirtualtouchtissuesquantificationLiverfibrosis早期准确判断肝脏纤维化程度.并采取积极有硬化患者肝脏SWV并结合病理学检查,评价VTQ效的治疗措施.可延缓疾病进展,减少肝硬化及其并技术对肝脏纤维化临床诊断价值。发症的发生。肝活检病理学检查是目前评价肝纤维化的金标准.但因其有创性往往难以被患者接受。声1材料与方法触诊组织量化(virtualtouchtissuequantific
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