DWI与1H-MRS在新生儿低血糖脑损伤中的应用价值.pdf

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1、CHINESEJ0URNALOFCTAN【)MR1．APR．2()14．Vo1．12．No，2TolaINo．55TheClinica1ValueofDiffusionWeightedImagingandProtonMagneticResonanceSpectroscopyinNeonatalHypoglycemic论著EncephalOpathV木MAHai—feng，OUNin—feng，ZHONGXu，etal，11)epamnentofRadiologT，Hexi,mMemorialAfiliatedHospitalofSouthernMedicalUniversit

2、y，Guangzhou，Guangdongprovince，511400China．2Neonatology，HexianMemorialAfiliatedHospitalofSouthernDWI与lH-MRS在新生MedicalUniversity，Guangzhou，Guangdongprovince，511400ChinaJLtl~血糖脑损伤中LAbs臼ct]ObjectiveToinvestigatethevalneofI)iffnsionWeightedhnagil,g(1)WI)的应用价值★andProtonMagneticResonanceSpectrosco

3、py(H—MRS)inneonatalhypoglycmnicencephalopathy(NHE)．Me~o&Thecasegroup"A：as17patientsofNHEdiagnosedbyMRIand17hypoglycemicneonatalhadI10encepllalopathy(Controlgrmlp)．Both1．南方医科大学附属何贤纪念医院ofthemreceivedthescanincludingconventionalMRI．DWIandH—MKSAreasof放射科(广东广州511400)lnetabolizingprodnctionnnderw

4、avecrestandapparentdifusioncoet}qcient(A1)(：)values2．南方医科大学附属何贤纪念医院wererecordedforstatisticalanalysis．RlIConlparedwithcontrolgroup．thecase新生儿科(广东广州511400)grouphadlowermeanlowestbloodglucoselevel(p<()．()1)．Casegronp’sdurationof马海锋欧宁锋钟旭吴静hypoglycenfiawaslongerthancontrolgroup’s(p<1)．《)1)．Betw

5、eencontrolgj'oupandcasegroup，thediferenceofLac／Cr，NAA／Crinoccipitalandparietallobe"wasstatistically孙庚喜李胜华昌爱武significant(P<0．O5)．Betweencontrolgroupandcasem1p，thediferenceofA1)(：vahlesinleftoccipita1andparietallobe"wasstatisticallysignificant(P

6、avemorespecificandsensitivethanconventionalMRIinNHE．Itcan和质子磁共振波谱(H-MRS)在新生儿低血糖脑损伤中的应用价值。方法收集17例providenlorepowerfulevidenceforclinicaldiagnosisandtreatment，anddeserx，etoin—经MRI确诊的低血糖性脑损伤新生儿(病depthresearchandextension．例组)的临床资料，并随机选取17倒同期叮words]DifusionMagneticResonancehnaging；lnagneticReson

7、anceSpectroscopy；单纯性低血糖但MRI正常的新生儿为对照组，病例组及对照组均行常规MRI、DWIEncephalopathy；Hypoglycemic；Neonata和H—MRs扫描，记录代谢产物H—MRs波峰下面积和表面弥散系数(ADc)值，并进行比较。结暴病例组平均最低血糖值低于对照组(P<0．01)，低血糖持续时间长于新生儿低血糖脑损伤，是新生)brae期m低血糖导致的中枢神经系对照组(P<0．01)。病例组左侧顶枕叶的乳酸／肌酸比值(Lac／Cr)较对照组升高，N统损伤性疾病，是