欢迎来到天天文库
浏览记录
ID:54369697
大小:835.91 KB
页数:6页
时间:2020-04-30
《乙型肝炎病毒相关性肝癌前C区变异与外周血T淋巴细胞亚群的关系.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·498·ChineseHepatology,July.2014,Vol.19,No.7·论著·乙型肝炎病毒相关性肝癌前C区变异与外周血T淋巴细胞亚群的关系王晓霖黄少军【摘要】目的探讨HBV前C区1896变异与乙型肝炎病毒相关性肝癌患者外周血T淋巴细胞亚群之间的关系。方法采用特异性引物PCR检测120例HBV相关性肝癌患者前C区1896变异,并用流式细胞仪检测外周血T淋巴细胞亚群的变化。以20名健康献血者作为健康对照组。结果120例乙肝相关性肝癌中前C区1896变异检出率为65%;其前C区1896变异构成比在≥
2、50岁与<50岁患者间的差异无统计学意义(2χ=0.024,P=0.878);HBV前C区1896突变株感染和野生株感染的肝癌患者性别差异无统计学意义(2χ=0.899,P=0.343),前C区1896突变株感染肝癌患者+、CD4+、CD8+HBVDNA定量明显高于野生株感染的肝癌患者(t=7.01,P<0.05);HBV相关HCC组CD3T淋巴细胞百分数以及CD4+/CD8+比值明显低于健康对照组(P<0.01),而CD8+T淋巴细胞百分数明显高于正常对照组(P<+、CD4+、CD8++/CD8+比值明显低于
3、野生株感0.01);前C区1896突变株感染肝癌患者CD3T淋巴细胞百分数以及CD4染的肝癌患者(P<0.01),而CD8+T淋巴细胞百分数明显高于野生株感染HCC患者(P<0.01)。结论HBV前C区1896突变株感染的乙肝相关性肝癌患者较HBV野生株感染的肝癌患者存在更严重的T淋巴细胞亚群失衡,这种紊乱可能参与了HBV前C区1896突变株感染导致的肝癌过程。【关键词】乙型肝炎病毒;肝细胞癌;T细胞亚群RelationshipofhepatitisBViruspreCregionmutationwithper
4、ipheralbloodTlymphocytesubsetsofhepatitisBrelatedhepatocellularcarcinomaWANGxiao-lin,HUANGshao-jun.SecondDepartmentofGastroenterology,XiangyangCentralHospital,Xiangyang441021,ChinaCorrespondingauthor:Huangshao-jun,Email:164535917@qq.com【Abstract】ObjectiveToi
5、nvestigatetherelationshipofhepatitisBVirus(HBV)preCregion1896mutationwithperipheralbloodTlymphocytesubsetsofhepatitisBrelatedhepatocellularcarcinoma(HCC).MethodsIn120patientswithhepatitisBrelatedHCC,thespecificprimersofpolymerasechainreaction(PCR)wasusedtode
6、tectthe(HBV)preCregion1896mutation,andtheTlymphocytesubsetsinperipheralbloodweredetectedbyflowcytometry.Atotalof20healthysubjectswereenrolledashealthycontrolgroup.ResultsIn120hepatitisBrelatedHCC,therateofHBVpreCregion1896mutationwas65%;Nosignificantdifferen
7、cewasfoundintheproportionofHBVpreC1896mutationbetween≥50years2and<50years(χ=0.024,P=0.878);NoneoftheHCCWithHBVpreC1896mutationgroupshowedasignificantly2differentsexfromthatdetectedinHCCWithwild-typestraingroup(χ=0.899,P=0.343);TheHBV-DNAloadinginHCCWithHBVpr
8、eC1896mutationwashigherthanthatinHCCWithwild-typestrain(t=7.01,P<0.05).InhepatitisB+++relatedHCCgroup,thepercentageofCD3Tcell,thepercentageofCD3Tcell,thepercentageofCD4Tcelland+++CD4T/CD8ratiowe
此文档下载收益归作者所有