资源描述：
《外周血泌乳素水平及t淋巴细胞亚群相关性探究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、外周血泌乳素水平及T淋巴细胞亚群相关性探究【摘要】目的本通过研究外周血PRL水平与T淋巴细胞亚群变化的相关性,以探讨泌乳素(PRL)与免疫系统变化的关系。方法检测100例垂体腺瘤患者及56例体检健康人外周血中CD4�+CD25�+、CD3�+、CD3�+CD4�+及CD3�+CD8�+的T淋巴细胞水平;并测定其外周血中PRL水平。结果病例组外周血CD3�+T淋巴细胞显著低于健康人组(P0�05);病例组外周血CD4�+CD25�+T淋巴细胞为显著高于健康人组(P100ng/ml组(P0�05)。结论CD3�+T淋巴细胞的减少可能是
2、垂体肿瘤细胞本身刺激CD4�+CD25�+T淋巴细胞的增生,导致外周血IL�2减少,从而抑制了T淋巴细胞的活化和增殖。外周血PRL>100ng/ml组外周血PRL显著升高,通过刺激各种细胞因子的分泌,而进一步促进T淋巴细胞的活化及增殖,同时,外周血中高PRL可直接抑制外周血T淋巴细胞的凋亡。�【关键词】泌乳素;T淋巴细胞;垂体腺瘤��ThestudyoftherelevanceofPRLandT�lymphocytesubsetsintheperipheralblood11YUJing,CHENLei,SUZhi�guo,etal
3、.DepartmentofBrainfaculties,FifthCentralHospitalofTiangjin,Tianjing300450,China�【Abstract】ObjectiveToinvestigatetherelationshipbetweenPRLandimmunesystem,thelevelofPRLandthechangesofT�lymphocytesubsetsweredetectedintheperipheralblood�Therelevanceofthemwasalsoanalyzed�M
4、ethods100patiententswithpituitaryadenomaand56peoplewereused�TheperipheralbloodofeverypersonwascollectedfordeterminingthelevelsofT�lymphocytesubsetsofCD4��+�CD25��+�,CD3��+�,CD3��+�CD4��+�andCD3��+�CD8��+�withflowcytometry�ThelevelsofPRLinperipheralbloodwereomitmeasure
5、datthesametimewiththemethodofmagneticseparationenzymeimmunoassayaswell�ResultsTheamountofCD3��+�lymphocytesintheperipheralbloodofpatientswassignificantlylowerthanthatinthecontrolgroup(P0�05)�TheamountofCD3��+�CD4��+�11lymphocytesintheperipheralbloodofpatientswasnotsig
6、nificantdifferent(P>0�05),andtheamountofCD3��+�CD4��+�lymphocytesinthepatientswhosePRLlevelwaslessthan100ng/mlwasnodifferentfromthepersonsthatinthepatientswhosePRLlevelwasexceeded100ng/ml(P0�05),andtherewasnosignificantdifferencebetweenthegroupswhichgroupedthepatients
7、intothePRLlevels�TheamountofCD4��+�CD25��+�lymphocytesintheperipheralbloodofpatientswassignificantlyhigherthanthatinthenormalgroup(P【Keywords】Prolactin;Tlymphocyte;Pituitaryadenoma�神经、内分泌和免疫系统在功能上是一个整体,它们之间相互作用、相互制约,对机体功能实施精密的调节��[1]�11。垂体是神经内分泌器官,可以分泌各种激素,对机体的内分泌系统进行
8、调控,在中枢神经系统的主导控制下,通过神经�内分泌�免疫网络的整合,协调有序地调控机体的功能,使机体对内外环境的刺激产生统一的适应性反应,以维持稳态��[2]�。同时研究证实,免疫细胞上有很多神经递质和激素的受体,神经内分泌系统通过自分泌或旁分泌的
