奈达铂或顺铂联合调强放疗治疗局部晚期鼻咽癌的疗效.pdf

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1、墨l3年4月第39卷第82013，Vo139，No．8论著奈达铂或顺铂联合调强放疗治疗局部晚期鼻咽癌的疗效陈绍俊黄海欣黄东宁李桂生【摘要】目的探讨奈达铂或顺铂联合调强放疗(IMRT)治疗局部晚期鼻咽癌的临床疗效及毒副反应。方法8O例局部晚期鼻咽癌患者随机均分为奈达铂组和顺铂组，均接受IMRT；在放疗第1、22、43天分别静脉滴注奈达铂或顺铂80mg／mz，评价两组疗效及毒副反应。结果两组近期鼻咽肿瘤及颈部淋巴结完全缓解率、2年局部控制率、2年无远处转移生存率相仿(P>o．05)。奈达铂组恶心呕吐发生率低于顺铂组(37．5vs．77．5％)(P

2、Plt下降发生率高于顺铂组(25．0Xvs．5．0X)(P

3、ancednasopharyng~carcinomaCHENShaojun．HUANGHaixin，HUANGDongning，eta1．DepartmentD，Oncology，FourthAffiliatedHospital，GuangxiMedicalUniversity，Liuzhou545005，CHINAIAbstract]ObjectiveToinvestigatetheclinicalefficacyandtoxicityofnedaplatinorcisplatincombinedwithintensity-modulatedradiationth

4、erapy(IMRT)inthetreatmentofpatientswithlocoregionallyadvancednasopharyngealcarcinoma(NPC)．MethodsEightypatientswithlocoregionallyadvancedNPCwereequallyrandomizedinto2groupsofN(intravenousinfusionofnedaplatin80mg／montheIst，22ndand43rddayafterT)andC(intravenousinfusionofcisplatin80nag／me

5、onthe1st，22nd，43rddayafterIMRT)．Theclinicalefficacyandtoxicityoftwogroupswerecompared．ResultsThecompleteresponserateinshort-term．the2-yearlocal-regionalcontrolrateandthe2-yeardistantmetastasis-freesurvivalrateoftwogroupsweresimilar(P>O．05)．Theincidenceofnauseaandvomitingwaslower(37．5vs

6、．77．5)，butthatofgradeⅢand1Vthrombocytopeniawashigher(25．Ovs．5．0X)，ingroupNthanthoseingroupC(P<0．05)．ConclusionTheclinica1efficacyofnedaplatincombinedwithIMRTisaseffectiveascisplatincombinedwithIMRTinthetreatmentofpatientsWithlocoregionallyadvancedNPC．Theformerhaslowerincidenceofgastroi

7、ntestinalsideeffects，buthigherincidenceofgradeⅢandIVthrombocytopenia．[Keywords]Nasopharyngealcarcinoma；Intensity-modulatedradiationtherapy；Nedaplatin；Cisplatin[JiangsuMedJ，April2013，39(8)i931—934．]作者单位：545005广西医科大学第四附属医院肿瘤科通讯作者：黄海欣E-mail：huanghaixin@china．com．cn[3]MatsudairaK，MaedaK，