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1、奥曲肽联合经动脉插管化疗栓塞治疗伴肝换化肝细胞癌來源：创新医学网医学编辑部推荐作者：陆建勋，马亦龙，罗彪作者单位：1.右江民族医学院附屈医院肿瘤科，广西百色533000;2.广西医科人学附属肿瘤医院介入科，广西南宁530021【摘要】日的评价奥曲肽联合经动脉插管化疗栓塞(TACE)治疗伴肝换化肝细胞癌的临床效果。方法选择Child-Pugh评分A或B级伴肝换化肝细胞癌患者共55例。实验组24例，行TACE术后第1天开始使用奥山肽0.2mg皮卜-注射，每天2次。对照纽.31例，接受TACE治疗。每3个月进行1
2、次评价。对两组6个月及1、2、3年的生存率进行比较。结果两组均无CR,实验组中16例PR,有效率为66.67%o对照组中II例PR,有效率为35.48%。两组有效率差异有显著性(PvO.05)。实验组3年生存率为45.83%,而对照组3年生存率为19.35%o两组3年生存率差异有显著性(PvO.05)。实验组中位生存期为31个月，对照组中位生存期为20个月。实验组屮位TTP为9个月，对照组为6个月。奥曲肽副作川主要为轻度腹泻。结论奥曲肽联合TACE治疗伴肝换化肝细胞癌有明确的效果。【关键词】奥曲肽;肝硕化;
3、肝细胞癌;化学栓塞，治疗性OctreotideincombinationwithtranscatheterarterialchemoembolizationforhepatocellularcarcinomaassociatedwithlivercirrhosisLUJian-xun,MAYi-long,LUOBiao1.DepartmentofOncology,theAffiliatedHospitalofYoujiangMedicalCollegeforNationalities,Baise,Guang
4、xi533000China;2.DepartmentofInterventionalRadiology,AffiliatedTumorHospitalofGuangxiMedicalUniversity,Nanning,Guangxi530021,ChinaAbstract:ObjectiveThisarticleistoevaluatetheeffectsofoctreotideincombinationwithtranscatheterarterialchemoembolization(TACE)for
5、hepatocellularcarcinomacomplicatedwithlivercirrhosis.MethodsFifty-fiveconsecutivepatientsinChild-PughclassificationAandBwereadmittedintothe3-yeartrial.Twenty-fourpatientsintheoctreotidegroupreceivedoctreotide0.2mgIHtwiceadayfollowingthetreatmentofTACEonday
6、1・Thirty-onepatientsreceivedTACEalonewereenrolledintothecontrolgroup.Theefficacywereassessedonceevery3months-Acomparisonofthe6-month、l-year^2-yearand3-yearsurvivalratebetweenthetwogroupswereperformed.ResultsNocompleteresponsewasgotinbothgroups・Intheoctreot
7、idegroup,partialresponse(PR)wasgotin16(66.67%)ofthe24patients,whereasinthecontrolgroup,PRwasachievedin11(35.48%)ofthe31patients.Therewasstatisticalsignificantdifferenceinresponseratebetweenthetwogroups(Pv0・05)・The3-yearoverallsurvivalrateoftheoctreotidegro
8、upandthecontrolgroupwere45.83%and19.35%,respectively・Therewasstatisticalsignificantdifferencein3-yearoverallsurvivalratebetweenthetwogroups(P<0.05).Theoverallsurvivalrateoftheoctreotidegroupwassignificantlyhi
