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时间:2020-04-02
《血清降钙素原对骨折术后感染的诊断价值_纪强.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、534中国临床研究2012年6月第25卷第6期ChineseJournalofClinicalResearch,June2012,Vo1.25,No.6·论著·血清降钙素原对骨折术后感染的诊断价值纪强李颖韩礼纲【摘要】目的探讨在骨折术后感染中血清降钙素原(PCT)水平检测的诊断价值。方法2008年9月至2011年9月骨折术后感染患者30例为感染组,同期未发生感染者30例为非感染组。检测2组血清PCT和C-反应蛋白(CRP)的水平,对比两指标在诊断骨折术后感染诊断中的敏感度和特异度。结果PCT水平在感染组明显高于非感染组〔(8.68±2.73)vs(0.18±0.09)ng/ml,P<0
2、.01〕。PCT和CRP对骨折术后并发感染诊断的敏感度分别是93.3%、100.0%,特异度分别是90.0%、10.0%,阳性预测值分别为90.3%、52.6%,阴性预测值分别为93.1%、100.0%。PCT对骨折术后并发感染的特异度和阳性预测值高于CRP(P均<0.01)。结论PCT可用于诊断骨折术后感染,不易受创伤及手术因素干扰,具有较高敏感度和特异度。【关键词】骨折;感染;降钙素原;C-反应蛋白;诊断中图分类号:R683R63文献标识码:A文章编号:1674-8182(2012)06-0534-02*Thediagnosticvalueofprocalcitoninforpos
3、toperativeinfectioninpatientswithbonefractureJIQiang,LI*Ying,HANLi-gang.DepartmentofSpineSurgery,SecondAffiliatedHospital,QingdaoUniversityMedicalCollege,Qingdao266042,China【Abstract】ObjectiveToexplorethediagnosticvalueofserumprocalcitonin(PCT)forpostoperativeinfectioninpa-tientswithbonefracture
4、.MethodsEligible30patientswithbonefracturecomplicatedpostoperativeinfectionfromSeptember2008toSeptember2011wereservedasinfectiongroup,and30caseswithoutcomplicationsofpostoperativeinfectioninthesametimewereselectedasno-infectiongroup.ThelevelsofserumPCTandC-reactiveprotein(CRP)wasmeasured,andthei
5、rsensibilityandspecificityfordiagnosingpostoperativeinfectioninpatientswithbonefracturewerecompared.ResultsPCTlevelininfectiongroupwassignificantlyhigherthanthatinno-infectiongroup〔(8.68±2.73)vs(0.18±0.09)ng/ml,P<0.01〕.ThesensibilitiesofPCTandCRPfordiagnosingpostoperativeinfectionofpatientswithb
6、onefracturewere93.3%and100.0%respectively,andthespecificitieswere90.0%and10.0%respectively.ThepositivepredictivevaluesofPCTandCRPfordiagnosingpostoperativeinfectionofpatientswithbonefracturewere90.3%and52.6%respectively,andtheirnegativepredictivevalueswere93.1%and100.0%,respectively.Thespecifici
7、tyandthepositivepredictivevalueofPCTfordiagnosingpostoperativeinfectionofpatientswithbonefracturewereobviouslybetterthanthoseofCRP(allP<0.01).Con-clusionsPCTcanbeusedindiagnosingpostoperativeinfectionoffracture,becauseitisno
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