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1、急诊大剂量应用可达龙治疗顽固性恶性室性心律失常疗效及安全性的临床研究泰山医学院JOURNALOFTAISHANMEDICALOOLLEGEVO1.26NO.32005233急诊大剂量应用可达龙治疗顽固性恶性室性心律失常疗效及安全性的临床研究刘明,张红欣•，李波,梁文波，程宽，李清(1•泰安市中心医院急救中心，山东泰安27100;2•泰安卫校，山东泰安271000;3.复旦大学附属I矢院上海200000)摘要:冃的探讨并总结急诊应用大剂量可达龙(Amiodarone,Am),即胺碘酮治疗恶性顽固性室性心律失常的疗
2、效及安全性的用药经验•方法选择对常规抗心律失常药物治疗无效的67例患者,男41例，女26例，年龄46.7±14.8(45-75)岁.静脉注射负荷量Am,3〜5mg/kg,用生理盐水稀释至20ml17〜15min内注入，继之以1.0〜1.5mg/n〜n静脉泵入维持，若心律失常控制不满意时，每隔30min后再静注75〜15()mg.静脉应用同时口服可达龙600-1200mg/d,用药2〜8天，平均6天•结果第1个24h可达龙静脉用量1678±285(1489〜2316)mg.27例顽固性心律失常24h内获得完全控制
3、(显效),37例36h-60h得以控制(有效)，其中2例并用电复律成功,1例因心源性休克死亡.结论急诊大剂量静脉应用可达龙治疗顽固性恶性室性心律失常疗效佳,安全性好，副作用少，值得推广应用.关键词:室性早搏;室性心动过速;心室颤动;胺碘酮;临床研究中图分类号:R541.7文献标识码:A文章编号:1004—7115(2005)03—0233—03Clinicalresearchofcurativeeffectandsecurityofrefractorinessandmalignantventriculararr
4、hythmiacuredwithlargedoseAmiodaroneinemergencycasesLIUMing,ZHANGHong-.:cin,LIt3o,LIANGWen—bo,CHENGKuan,LIQing(EmergencyCentre,FimtTeachingHospitalofTaishanMedicalCollege5Taian271000,China)Abstract:Objective:Toinvestigateanclsummarizesomecurativeeffectandsecu
5、rity9frefractoryandmalignantyen一triculararhythmiaarrhythmiatreatedwithlargedoseofamiodarone.Methods:Sixty-sevencasesofrefractorypatients,41malesand26femalesaverageage:46.7土14.8(45〜75)?whohadnotbeentreatedeffectivelywithroutinedrugs.weretreatedwithAmi(Marone.
6、Thepatientsweretreatedwiththedose(3〜5mgperkg)ofamiodaroneattenuatedto20mlwithisotonicNachlorideintravenousinjectionwithin7〜15minutes.Thenamiodaronewasintravenouslyinjectedtomaintainwithin1.0〜1.5mgperminutewithvenouspump.Ifarhythrniawasnotcontrolled.amiodaron
7、eWasintraveno—uslyinjectedevery30minutes.Simultaneouslythepatentsorallyreceivedamiodaronum600—1200nagperday,lasting28days?withanaverageof6days.Results:Theamiodafonum1678±285(1489—2316}mgWasusedinthefirstday(24hours),and27casesmalignantventriculararhythmiawer
8、eobviouslycontrdled.37caseswereinsomeway.Oneofthemwasdeadbecauseofcardiacshock.andtwocaseswererescuedwithelectricalconversion.ConclusionThelargedoseofAmiodaroneiseffectiveintheemergencycasesofem
