增生性玻璃体视网膜病变组织中的单核细胞趋化因子-1的意义.doc

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6、6l0AriINAeo6pA6uoi1y3i°lPVR66d3AapABi3E6DpvWx4-✓〜OA.ijjJKeywords:vitreoretinopathy£_'proliferative;monocytechemoatlractantprotein~l;macrophages;t~lymphocytes;immunohistochemistryiijjAbstract:AIMToinvestigatetherelationshipbetweenthepresenceofMC卩-1andmacrophagesandT-1ymphocyt

7、esinspecimensobtainedfromretinaldetachmentandPVReyes・ijj;METHODSSpecimenswereobtainedduringretinalsurgery£-iincludingcellularcomponentsofsubretinalfluidsinrhegmatogenousretinaldetachment£/・RD£©£「f1uidscol1ectionsduringvitrectomyforPVRgradeB£_,andepiretinalmem-branesfromPVRgr

8、adeCorD.Immunohistochemicaldetec-tionwasperformedtoexaniinethedistributionofMCP-1ndthepresenceofCD68orCD3positivecel1sinthesespeci©zmens.RESULTSTheexpressionofMCP-lwasnegativeorveryweakincellsofsubretinaifluidfromRD・Asafunctionoftheinci'e8seofPVRgrade£_iMC卩-1expressionbeeame

9、strongerwhi1etherateofCD68£*"+£©/CD3£+£©decreased.CONCLUSTONMCP-1maymodulatethewoundhealingaf-terretinaldetachmentandtheforniationofepiretindlmem-branesinPVR.iiiiOOyNOijjjOoEuDO2£A§iaEOl0A口2；±a£**proliferativevitreo-retinopathy£VR£©EoOUNUAUxed^zzEEOu°I)JiAd»ddi0Ea±iid£^6eiaA

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