增生性玻璃体视网膜病变组织中的单核细胞趋化因子1的意义

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2、ÎÓëµÄÒ»ÖÖÑÛÄÚ´´ÉËÐÞ¸´·´Ó¦.µ¥ºËϸ°ûÇ÷»¯µ°°×-1£¨MCP-1£©¶Ô¾ÞÊÉϸ°ûºÍÁÜ°Íϸ°ûÓÐÌØÒìÇ÷»¯×÷ÓÃ.±¾Ñо¿Ä¿µÄÔÚÓÚÁ˽âÊÓÍøĤÍÑÀëºó²»Í¬Ê±ÆÚµÄ×éÖ¯ÖÐMCP-1µÄ±í´ïÓë¾ÞÊÉϸ°ûºÍÁÜ°Íϸ°ûµÄ¹Øϵ.·½·¨Ñ¡ÓÃÊÓÍøĤÊÖÊõÈ¡²Ä±ê±¾£¬°üÀ¨¿×Ô´ÐÔÊÓÍøĤÍÑÀëµÄÊÓÍøĤÏÂÒºÖеÄϸ°û³É·Ý£¬B¼¶PVR²£Á§ÌåÊÖÊõ¼¯È¡ÎïÒÔ¼°PVRC/DµÄ

3、ÊÓÍøĤÔöֳĤ£¬ÃâÒß×黯·¨¼ì²âÆäÖÐMCP-1£¬CD68ºÍCD3±í´ï״̬.½á¹ûÊÓÍøĤÏÂÒºÖÐϸ°û³É·ÝMCP-1µÄ±í´ï¾ùΪÒõÐÔ»òÈõÑôÐÔ£¬B¼¶PVRÊÖÊõ¼¯È¡ÎïÒÔ¼°ÔöֳĤÖУ¬MCP-1±í´ïÑôÐԳ̶ÈËæPVRµÈ¼¶µÄÉý¸ß¶øÖð½¥Ôö¸ß.CD68ÑôÐÔϸ°û£¨¾ÞÊÉϸ°û£©ÓëCD3ÑôÐÔϸ°û£¨T-ÁÜ°Íϸ°û£©µÄ±ÈÀýËæPVR²¡±ä³Ì¶ÈµÄÔö¼Ó¶ø½µµÍ.½áÂÛMCP-1¶ÔÊÓÍ

4、øĤÍÑÀëºóµÄÓúºÏ¹ý³ÌºÍPVRÔöֳĤµÄÐγÉÓе÷½Ú×÷ÓÃ.9¡¡¡¡Keywords:vitreoretinopathy£¬proliferative;monocytechemoatlractantprotein-1;macrophages;t-lymphocytes;immunohistochemistry¡¡¡¡Abstract:AIMToinvestigatetherelationshipbetweenthepresenceofMCP-1andmacrophagesandT-lymphocytesinspecim

5、ensobtainedfromretinaldetachmentandPVReyes.¡¡¡¡METHODSSpecimenswereobtainedduringretinalsurgery£¬includingcellularcomponentsofsubretinalfluidsinrhegmatogenousretinaldetachment£¨RD£©£¬fluidscollectionsduringvitrectomyforPVRgradeB£¬andepiretinalmem-branesfromPVRgradeCorD.Immunohist

6、ochemicaldetec-tionwasperformedtoexaminethedistributionofMCP-1£¬andthepresenceofCD68orCD3positivecellsinthesespeci©´mens.RESULTSTheexpressionofMCP-1wasnegativeorveryweakincellsofsubretinalfluidfromRD.AsafunctionoftheincreaseofPVRgrade£¬MCP-1expressionbecamestrongerwhiletherateofC

7、D68£¨+£©/CD3£¨+£©decreased.CONCLUSIONMCP-1maymodulatethewoundhealingaf-terretinaldetachmentandtheformationofepiretinalmem-branesinPVR.¡¡¡¡0ÒýÑÔ9¡¡¡¡ÔöÉúÐÔ²£Á§ÌåÊÓÍøĤ²¡±ä£¨proliferativevitreo-retinopathy£¬PVR£©ÊôÓÚÑÛÄÚ×éÖ¯´´ÉËÓúºÏµÄÒ»ÖÖÌØÊâ±íÏÖ£¬ÓëÌåÄÚÆäËü×éÖ¯µÄËðÉËÐÞ¸´¹ý³ÌÒ»Ñù£¬

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