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1、S100B蛋白测定在老年肺癌根治术后认知功能障碍评价中的临床价值研究中国人民解放军第一五三中心医院呼吸内科河南郑州450042【摘要】目的：为了了解SlOOβ蛋白与术后认知功能的关系，探索血清SlOOβ蛋白水平测定在老年肺癌根治术后认知功能障碍评价中的临床价值。方法：采用前瞻性研究方法，选取我院近年來肺癌择期手术患者80例作为手术组，及同期健康体检者80例作为对照组，分别测定两组研究对象术前24h及术后30min>6h>24h、72h>1周血清SlOOβ蛋白水平，同时对两组研究对象作术前24h及术后6h、24h、72h、1周的MMSE评分，所得结果以均数&p
2、lusmn;标准差表示，并应用统计学软件进行统计分析。结果：手术组术后30min>6h、24h、72h血浆SlOOβ蛋白水平较术前及同期对照组明显升高(P<0.05),表明术后脑损伤的存在。两组MMSE评分比较，手术组术后6h、24h、72h的MMSE评分较术前及同期对照组值明显降低(P<0.05),反映手术组患者术后早期认知功能障碍的存在，且评分越低认知功能障碍越严重。结论：血清SlOOβ蛋白水平可作为反映术后脑损伤的指标，且血清SlOOβ蛋白浓度与损伤程度具有相关性，检测血清SlOOβ蛋白水平有利于评价术后认知功能障碍的严重程度，能
3、指导老年肺癌根治术患者术后早期的认知功能障碍治疗及判断预后。【关键词】老年；肺癌根治术后;SlOOβ蛋白;认知功能障碍ClinicalValueofSlOOβproteindeterminationinevaluatingthecognitivedysfunctionofelderlylungcancerradicalpostoperativeYehejiang(DepartmentofRespiratoryMedicine,ThePeople'sLiberationArmyfirstfifty-threeCentralHospital,Zhengzhou450042
4、,China)[Abstract]Objective:TounderstandtherelationshipbetweenproteinandcognitivefunctioninpatientsSlOOβexploreSlOOβproteinserumlevelsweremeasuredinelderlylungcancerclinicalvalueassessmentofradicalpostoperativecognitivedysfunction.Methods:Aprospectivestudyoflungcancerpatientsinourhospita
5、linrecentyears,80casesofelectivesurgeryasthesurgeryoup,and80casesofhealthyvolunteersasacontrolgroup,twogroupsofsubjectsweremeasuredbeforesurgery24h,after30min,6h,24h,72h,lweekSlOOβserumproteinlevelsandbothgroupsbeforeandafter24h6h,24h,72h,1weekMMSEscore,themeasuredresultsareexpressedasmean&p
6、lusmn;standarddeviation,andusingstatisticalsoftwareforstatisticalanalysis.Results:surgerygroupafter30min,6h,24h,72hSlOOβplasmaproteinlevelscomparedwithpreoperativeandcon・currentcontrolgroupwassign讦icantlyhigher(P<0.05),describedthepreseneeofpostoperativebraindamage.MMSEscoresbetweenthetwo
7、groupsoverthesameperiod,aftersurgery6h,before24h,72hMMSEscoreandthesameperiodcomparedwiththatinthecontrolgroupwassignificantlylower(P<0.05),earlypostoperativecognitivedysfunctionsurgerygroup,andscoremoreThemoresever
